ArticleProceedings of the National Academy of Sciences of the United States of America2019
Autocrine regulation of mesenchymal progenitor cell fates orchestrates tooth eruption.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.
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Who cites it
98 citing papers in PubMed, 141 citations in OpenAlex.
- Single-Cell Virtual Perturbation Screening Identifies STAT3 as a Key Regulator of Dentinogenesis.Cell proliferation · 2026Article
- Embryonic and postnatal macrophages are necessary for proper tooth development and homeostasis.Nature communications · 2026Article
- Wnt-dependent ontogeny of acellular cementum-forming cementoblasts on the tooth root surface.Nature communications · 2026Article
- Microenvironment-mediated stem cell fate in periodontal tissue remodeling and repair.Bioactive materials · 2026Review
- Loss of PTH 1 receptor signaling in periodontal cells drives cementum dysfunction and molar ankylosis in mice.Bone research · 2026Article
- Identification of Smmhc-expressing mesenchymal cells in orofacial bone at single-cell resolution.Bone research · 2026Article
- Stem-cell regulation in periodontium formation and regeneration.Journal of bone and mineral metabolism · 2026Review
- Genetic Determinants of Primary Failure of Eruption: A Comprehensive Review of PTH1R Variants.Genes · 2026Review
- Wnt3a promotes in situ dentin formation through NKD1-MSX1 axis-mediated odontogenic differentiation of dental pulp stem cells.International journal of oral science · 2026Article
- Resolving tooth development at single-cell resolution: advancing dental regeneration.Frontiers in cell and developmental biology · 2026Review
- Single-cell RNA sequencing reveals genes relevant to periodontal therapy and periodontitis.Physiological genomics · 2025Article
- Mechanisms of primary failure of eruption: a new model of multidimensional framework.Progress in orthodontics · 2025Review
- Mx1-labeled pulp progenitor cells are the main contributors of odontoblast and dentin regeneration in murine molars.Experimental & molecular medicine · 2025Article
- Permanent first molar eruption failure in children: leading signs for early diagnosis.Progress in orthodontics · 2025Observational
- A Hedgehog-Foxf axis coordinates dental follicle-derived alveolar bone formation.Nature communications · 2025Article
- Wnt-directed CXCL12-expressing apical papilla progenitor cells drive tooth root formation.Nature communications · 2025Article
- A spatially organizedScience advances · 2025Article
- Control of alveolar bone development, homeostasis, and socket healing by salt-inducible kinases.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- The next generation of regenerative dentistry: From tooth development biology to periodontal tissue, dental pulp, and whole tooth reconstruction in the clinical setting.Regenerative therapy · 2025Review
- A novel PTH1R mutation causes primary failure of eruption via the cAMP-PI3K/AKT pathway.Progress in orthodontics · 2025Article
38 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Formation of functional skeletal tissues requires highly organized steps of mesenchymal progenitor cell differentiation. The dental follicle (DF) surrounding the developing tooth harbors mesenchymal progenitor cells for various differentiated cells constituting the tooth root-bone interface and coordinates tooth eruption in a manner dependent on signaling by parathyroid hormone-related peptide (PTHrP) and the PTH/PTHrP receptor (PPR). However, the identity of mesenchymal progenitor cells in the DF and how they are regulated by PTHrP-PPR signaling remain unknown. Here, we show that the PTHrP-PPR autocrine signal maintains physiological cell fates of DF mesenchymal progenitor cells to establish the functional periodontal attachment apparatus and orchestrates tooth eruption. A single-cell RNA-seq analysis revealed cellular heterogeneity of PTHrP
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.