Evidence map›Paper›PMID 30509985›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Mother-child transmission of epigenetic information by tunable polymorphic imprinting.

Brittany L Carpenter, Wanding Zhou, Zachary Madaj, Ashley K DeWitt, Jason P Ross, Kirsten Grønbæk, Gangning Liang, Susan J Clark, Peter L Molloy, Peter A Jones

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Article
  5. Article
  6. Non-coding 886 (Epigenetics · 2024
    Review
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  11. Review
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  18. Article
  19. Oocyte age and preconceptual alcohol use are highly correlated with epigenetic imprinting of a noncoding RNA (Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  20. International journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Brittany L CarpenterCenter for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503.
Wanding ZhouCenter for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503.
Zachary MadajCenter for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503.
Ashley K DeWittCenter for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503.
Jason P RossNutrition and Health Program, CSIRO Health and Biosecurity, North Ryde, NSW 2113, Australia.
Kirsten GrønbækDepartment of Hematology, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
Gangning LiangDepartment of Urology, University of Southern California, Los Angeles, CA 90089.
Susan J ClarkGenomics and Epigenetics Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
Peter L MolloyNutrition and Health Program, CSIRO Health and Biosecurity, North Ryde, NSW 2113, Australia.
Peter A JonesCenter for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503; peter.jones@vai.org.
Van Andel Institute · USCSIRO Health and Biosecurity · AUGarvan Institute of Medical Research · AUUniversity of Copenhagen · DKUniversity of Southern California · US

Funding

Targeting DNA Methylation and the Cancer EpigenomeR35CA209859 · NCI · VAN ANDEL RESEARCH INSTITUTE · PI PETER A JONES · 2017 to 2026
$11.9M
Using DNA methylation markers to improve the predictive accuracy and utility of needle biopsiesfor determining prostate cancer aggressivenessR21CA201865 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GILL, INDERBIR, LIANG, GANGNING · 2016 to 2017
$395k
NCI NIH HHS R21 CA201865NCI NIH HHS R35 CA209859
6 · The paper itself

Abstract

Genomic imprinting mediated by DNA methylation restricts gene expression to a single allele determined by parental origin and is not generally considered to be under genetic or environmental influence. Here, we focused on a differentially methylated region (DMR) of approximately 1.9 kb that includes a 101-bp noncoding RNA gene (

Indexed as

DNA MethylationEpigenomicsGenomic ImprintingPolymorphism, GeneticAllelesBinding SitesCCCTC-Binding FactorChildChild, PreschoolDNA-Binding ProteinsFemaleGene Expression RegulationHaplotypesHumansMaternal AgeMicroRNAsCCCTC-Binding FactorCTCF protein, humanDNA-Binding ProteinsMicroRNAsMIRN886 microRNA, humanRNA, UntranslatedDNA methylationepigenetic inheritancenc886polymorphic imprintingVTRNA2-1

Identifiers

PMID30509985
PMCPMC6304996
OpenAlexW2902374889

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.