ArticleProceedings of the National Academy of Sciences of the United States of America2018
Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 57 citations in OpenAlex.
- Continuous UV irradiation played an inconclusive role in selecting the canonical genetic alphabet.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes.Chembiochem : a European journal of chemical biology · 2025Review
- Multicomponent Synthesis of C(8)-Substituted Purine Building Blocks of Peptide Nucleic Acids from Prebiotic Compounds.ChemistryOpen · 2024Article
- Heterogeneous photocatalytic degradation of antiviral drug didanosine mediated by rose bengal and TiOAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024Article
- Incorporation of inosine into DNA by human polymerase eta (Polη): kinetics of nucleotide misincorporation and structural basis for the mutagenicity.The Biochemical journal · 2023Article
- Prebiotic synthesis and triphosphorylation of 3'-amino-TNA nucleosides.Nature chemistry · 2022Article
- Trinity of G-tetrads and origin of translation.Biology direct · 2022Article
- Thermodynamic and Kinetic Sequence Selection in Enzyme-Free Polymer Self-Assembly inside a Non-equilibrium RNA Reactor.Life (Basel, Switzerland) · 2022Article
- Prebiotic Photochemical Coproduction of Purine Ribo- and Deoxyribonucleosides.Journal of the American Chemical Society · 2021Article
- Ribose Alters the Photochemical Properties of the Nucleobase in Thionated Nucleosides.The journal of physical chemistry letters · 2021Article
- 2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions.Nature communications · 2021Article
- Inosine in Biology and Disease.Genes · 2021Review
- Coenzymes and Their Role in the Evolution of Life.Angewandte Chemie (International ed. in English) · 2021Review
- A Potential Role for Aminoacylation in Primordial RNA Copying Chemistry.Biochemistry · 2021Article
- The virtual circular genome model for primordial RNA replication.RNA (New York, N.Y.) · 2021Article
- Assembly of a Ribozyme Ligase from Short Oligomers by Nonenzymatic Ligation.Journal of the American Chemical Society · 2020Article
- Deep sequencing of non-enzymatic RNA primer extension.Nucleic acids research · 2020Article
- Article
- Reconstruction and Characterization of Thermally Stable and Catalytically Active Proteins Comprising an Alphabet of ~ 13 Amino Acids.Journal of molecular evolution · 2020Article
- A Model for the Emergence of RNA from a Prebiotically Plausible Mixture of Ribonucleotides, Arabinonucleotides, and 2'-Deoxynucleotides.Journal of the American Chemical Society · 2020Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emergence of primordial RNA-based life would have required the abiotic synthesis of nucleotides, and their participation in nonenzymatic RNA replication. Although considerable progress has been made toward potentially prebiotic syntheses of the pyrimidine nucleotides (C and U) and their 2-thio variants, efficient routes to the canonical purine nucleotides (A and G) remain elusive. Reported syntheses are low yielding and generate a large number of undesired side products. Recently, a potentially prebiotic pathway to 8-oxo-adenosine and 8-oxo-inosine has been demonstrated, raising the question of the suitability of the 8-oxo-purines as substrates for prebiotic RNA replication. Here we show that the 8-oxo-purine nucleotides are poor substrates for nonenzymatic RNA primer extension, both as activated monomers and when present in the template strand; their presence at the end of a primer also strongly reduces the rate and fidelity of primer extension. To provide a proper comparison with 8-oxo-inosine, we also examined primer extension reactions with inosine, and found that inosine exhibits surprisingly rapid and accurate nonenzymatic RNA copying. We propose that inosine, which can be derived from adenosine by deamination, could have acted as a surrogate for G in the earliest stages of the emergence of life.
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