Evidence map›Paper›PMID 30509943›Full record

ArticleAntimicrobial agents and chemotherapy2019

Antibiotics Stimulate Formation of Vesicles in

Federica Andreoni, Masanori Toyofuku, Carmen Menzi, Ratchara Kalawong, Srikanth Mairpady Shambat, Patrice François, Annelies S Zinkernagel, Leo Eberl

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 1 synthesis or guideline pooled it, 133 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Outer membrane vesicles inMicrobial cell (Graz, Austria) · 2026
    Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Federica Andreoni *Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Masanori Toyofuku *Department of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Carmen MenziDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Ratchara KalawongDepartment of Plant and Microbial Biology, University of Zurich, Zurich, Switzerland.
Srikanth Mairpady ShambatDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Patrice FrançoisLaboratoire de Recherche Génomique, Service des Maladies Infectieuses, Centre Médical Universitaire, Geneva, Switzerland.
Annelies S Zinkernagel *Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland annelies.zinkernagel@usz.ch leberl@botinst.uzh.ch.ORCID 0000-0003-4700-1118
Leo Eberl *Department of Plant and Microbial Biology, University of Zurich, Zurich, Switzerland annelies.zinkernagel@usz.ch leberl@botinst.uzh.ch.ORCID 0000-0002-7241-0864
University of Zurich · CHUniversity of Tsukuba · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial membrane vesicle research has so far focused mainly on Gram-negative bacteria. Only recently have Gram-positive bacteria been demonstrated to produce and release extracellular membrane vesicles (MVs) that contribute to bacterial virulence. Although treatment of bacteria with antibiotics is a well-established trigger of bacterial MV formation, the underlying mechanisms are poorly understood. In this study, we show that antibiotics can induce MVs through different routes in the important human pathogen

Indexed as

Anti-Bacterial AgentsBacteriophagesCeftarolineCephalosporinsCytoplasmic VesiclesDaptomycinDNA, BacterialFloxacillinHumansLysogenyPeptidoglycanStaphylococcus aureusAnti-Bacterial AgentsCeftarolineCephalosporinsDaptomycinDNA, BacterialFloxacillinPeptidoglycanantibioticsbacteriophagesmembrane vesiclesStaphylococcus aureus

Identifiers

PMID30509943
PMCPMC6355553
OpenAlexW2902110571

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.