ArticleBiophysical journal2018
Characterizing Inner Pressure and Stiffness of Trophoblast and Inner Cell Mass of Blastocysts.
Article in Biophysical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Origin, fate and function of extraembryonic tissues during mammalian development.Nature reviews. Molecular cell biology · 2025Review
- MechanoBase: a comprehensive database for the mechanics of tissues and cells.Database : the journal of biological databases and curation · 2024Article
- Human embryonic stem cells maintain their stemness in three-dimensional microenvironment.In vitro cellular & developmental biology. Animal · 2024Article
- Effective mechanical potential of cell-cell interaction in tissues harboring cavity and in cell sheet toward morphogenesis.Frontiers in cell and developmental biology · 2024Article
- Plakoglobin is a mechanoresponsive regulator of naive pluripotency.Nature communications · 2023Article
- Robotic Intracellular Pressure Measurement Using Micropipette Electrode.Sensors (Basel, Switzerland) · 2023Article
- Article
- Transgenic force sensors and software to measure force transmission across the mammalian nuclear envelope in vivo.Biology open · 2022Article
- Mechanical regulation of chromatin and transcription.Nature reviews. Genetics · 2022Review
- Epithelial dynamics during early mouse development.Current opinion in genetics & development · 2022Review
- StemBond hydrogels control the mechanical microenvironment for pluripotent stem cells.Nature communications · 2021Article
- Mechanobiology of the female reproductive system.Reproductive medicine and biology · 2021Review
- Scanning Probe Microscopies: Imaging and Biomechanics in Reproductive Medicine Research.International journal of molecular sciences · 2021Review
- YAP-TEAD1 control of cytoskeleton dynamics and intracellular tension guides human pluripotent stem cell mesoderm specification.Cell death and differentiation · 2021Article
- Computational modelling unveils how epiblast remodelling and positioning rely on trophectoderm morphogenesis during mouse implantation.PloS one · 2021Article
- Epithelial-Mesenchymal Transition Drives Three-Dimensional Morphogenesis in Mammalian Early Development.Frontiers in cell and developmental biology · 2021Article
- The NEMP family supports metazoan fertility and nuclear envelope stiffness.Science advances · 2020Article
- Magnetic Micromanipulation forResearch (Washington, D.C.) · 2020Article
- Tissue rheology in embryonic organization.The EMBO journal · 2019Review
- Tissue stiffness at the human maternal-fetal interface.Human reproduction (Oxford, England) · 2019Observational
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has long been recognized that mechanical forces underlie mammalian embryonic shape changes. Before gastrulation, the blastocyst embryo undergoes significant shape changes, namely, the blastocyst cavity emerges and expands, and the inner cell mass (ICM) forms and changes in shape. The embryo's inner pressure has been hypothesized to be the driving mechanical input that causes the expansion of the blastocyst cavity and the shape changes of the ICM. However, how the inner pressure and the mechanics of the trophoblast and the ICM change during development is unknown because of the lack of a suitable tool for quantitative characterization. This work presents a laser-assisted magnetic tweezer technique for measuring the inner pressure and Young's modulus of the trophoblast and ICM of the blastocyst-stage mouse embryo. The results quantitatively showed that the inner pressure and Young's modulus of the trophoblast and ICM all increase during progression of mouse blastocysts, providing useful data for understanding how mechanical factors are physiologically integrated with other cues to direct embryo development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.