Evidence map›Paper›PMID 30509471›Full record

ArticleMethods in enzymology2018

Production and properties of enzymes that activate and produce carbon monoxide.

Rodney Burton, Mehmet Can, Daniel Esckilsen, Seth Wiley, Stephen W Ragsdale

Abstract read
In one paragraph

Article in Methods in enzymology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Journal of the American Chemical Society · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Rodney BurtonDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, United States.
Mehmet CanDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, United States.
Daniel EsckilsenDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, United States.
Seth WileyDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, United States.
Stephen W RagsdaleDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, United States. Electronic address: sragsdal@umich.edu.
University of Michigan · US

Funding

Enzymology of the Reductive Acetyl-CoA PathwayR37GM039451 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAGSDALE, STEPHEN WILEY · 2012 to 2021
$4.0M
NIGMS NIH HHS R37 GM039451
6 · The paper itself

Abstract

The chapter focuses on the methods involved in producing and characterizing two key nickel-iron-sulfur enzymes in the Wood-Ljungdahl pathway (WLP) of anaerobic conversion of carbon dioxide fixation into acetyl-CoA: carbon monoxide dehydrogenase (CODH) and acetyl-CoA synthase (ACS). The WLP is used for biosynthesis of cell material and energy conservation by anaerobic bacteria and archaea, and it is central to several industrial biotechnology processes aimed at using syngas and waste gases for the production of fuels and chemicals. The pathway can run in reverse to allow organisms, e. g., methanogens and sulfate reducers, to grow on acetate. The CODH and ACS intertwine to form a tenacious CODH/ACS complex that converts CO

Indexed as

Aldehyde OxidoreductasesArchaeaBacteria, AnaerobicCarbon DioxideCarbon MonoxideCoenzyme A LigasesMultienzyme ComplexesOxidation-Reductionacetate-CoA ligase (ADP-forming)Aldehyde OxidoreductasesCarbon DioxideCarbon Monoxidecarbon monoxide dehydrogenaseCoenzyme A LigasesMultienzyme ComplexesAcetyl-CoACarbon dioxide fixationCarbon monoxideElectron paramagnetic resonanceIron–sulfur enzymesMetalloenzymeNickel enzymesRapid kineticsSteady-state kinetics

Identifiers

PMID30509471
PMCPMC6309614
OpenAlexW2900489966

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.