ArticleBreast cancer research : BCR2018
Risk prediction for estrogen receptor-specific breast cancers in two large prospective cohorts.
Article in Breast cancer research : BCR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- A systematic review of prediction models for risk of breast cancer.BMC cancer · 2025Pooled it
- Long-term health consequences of central precocious/early puberty (CPP) and treatment with Gn-RH analogue: a short update.Acta bio-medica : Atenei Parmensis · 2023Pooled it
- Understanding the contribution of lifestyle in breast cancer risk prediction: a systematic review of models applicable to Europe.BMC cancer · 2023Pooled it
- The association between parity, age of first full term pregnancy and invasive lobular breast cancer: a case-only analysis.Cancer treatment and research communications · 2026Article
- Insights from the largest diverse ancestry sex-specific disease map for genetically predicted height.NPJ genomic medicine · 2025Article
- Curcumin as an antidote to atrazine on estrogen homeostasis and beyond: mechanistic insights from a targeted literature review.Frontiers in endocrinology · 2025Review
- Addition of polygenic risk score to a risk calculator for prediction of breast cancer in US Black women.Breast cancer research : BCR · 2024Article
- Risk assessment and clinical prediction model of planned transfer to the ICU after hip arthroplasty in elderly individuals.BMC surgery · 2023Article
- Expression-Based Diagnosis, Treatment Selection, and Drug Development for Breast Cancer.International journal of molecular sciences · 2023Article
- Neighborhood factors and triple negative breast cancer: The role of cumulative exposure to area-level risk factors.Cancer medicine · 2023Article
- Breast Cancer Risk Assessment Tools for Stratifying Women into Risk Groups: A Systematic Review.Cancers · 2023Review
- Machine learning algorithms to uncover risk factors of breast cancer: insights from a large case-control study.Frontiers in oncology · 2023Article
- Lipid exposure activates gene expression changes associated with estrogen receptor negative breast cancer.NPJ breast cancer · 2022Article
- Performance of polygenic risk scores for cancer prediction in a racially diverse academic biobank.Genetics in medicine : official journal of the American College of Medical Genetics · 2022Article
- Prospective evaluation of a breast-cancer risk model integrating classical risk factors and polygenic risk in 15 cohorts from six countries.International journal of epidemiology · 2022Article
- Risk assessment and prediction model of renal damage in childhood immunoglobulin A vasculitis.Frontiers in pediatrics · 2022Article
- A Validated Risk Prediction Model for Breast Cancer in US Black Women.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021Article
- Risk Factors Associated with Breast Cancer among Women in Addis Ababa, Ethiopia: Unmatched Case-Control Study.International journal of women's health · 2021Article
- Validation of two US breast cancer risk prediction models in German women.Cancer causes & control : CCC · 2020Article
- MicroRNA-26a-5p inhibits breast cancer cell growth by suppressing RNF6 expression.The Kaohsiung journal of medical sciences · 2019Article
Corrections and comments
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Authors and funding
35 authors at 20 institutions in 13 countries.
Funding
Abstract
backgroundFew published breast cancer (BC) risk prediction models consider the heterogeneity of predictor variables between estrogen-receptor positive (ER+) and negative (ER-) tumors. Using data from two large cohorts, we examined whether modeling this heterogeneity could improve prediction.
methodsWe built two models, for ER+ (Model
resultsParity, number of full-term pregnancies, age at first full-term pregnancy and body height were only associated with ER+ tumors. Menopausal status, age at menarche and at menopause, hormone replacement therapy, postmenopausal body mass index, and alcohol intake were homogeneously associated with ER+ and ER- tumors. Internal validation yielded a C-statistic of 0.64 for Model
conclusionsModeling heterogeneous epidemiological risk factors might yield little improvement in BC risk prediction. Nevertheless, a model specifically predictive of ER+ tumor risk could be more applicable than an omnibus model in risk assessment for chemoprevention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.