ArticleArthritis research & therapy2018
Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups.
Article in Arthritis research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evaluation of the Synovial Effects of Biological and Targeted Synthetic DMARDs in Patients with Psoriatic Arthritis: A Systematic Literature Review and Meta-Analysis.International journal of molecular sciences · 2023Pooled it
- Biopsy-Driven Synovial Pathophenotyping in RA: A New Approach to Personalized Treatment.Journal of personalized medicine · 2025Review
- The relationship between circulating and tissue biomarkers and OA-related pain: A systematic literature review.Osteoarthritis and cartilage open · 2025Review
- Minimally invasive ultrasound-guided biopsy of the common extensor tendon enthesis: a cadaveric study to standardise the technique.RMD open · 2025Article
- Article
- Exploring perinatal mesenchymal stromal cells as a potential therapeutic strategy for rheumatoid arthritis.Heliyon · 2025Review
- Immune checkpoint-induced arthritis: a comprehensive single-cohort descriptive analysis from clinical evaluation to histology.Frontiers in medicine · 2025Article
- Ultrasound-guided synovial tissue biopsy for people with rheumatoid arthritis: a micro-costing study.Rheumatology advances in practice · 2025Article
- A standardized approach to evaluation and reporting of synovial histopathology in two surgically induced murine models of osteoarthritis.Osteoarthritis and cartilage · 2024Article
- Article
- High-grade synovitis associates with clinical markers and response to therapy in chronic inflammatory arthritis:Frontiers in immunology · 2023Article
- The histopathological synovitis score is influenced by biopsy location in patients with knee osteoarthritis.Archives of orthopaedic and trauma surgery · 2022Article
- Synovial tissue metabolomic profiling reveal biomarkers of synovial inflammation in patients with osteoarthritis.Osteoarthritis and cartilage open · 2022Article
- Prediction of histology by B-mode and PD-mode ultrasound across different joint locations and diseases.RMD open · 2022Article
- Impact of the biopsy forceps size on histological analysis and performances of the histological scoring systems.Scientific reports · 2022Article
- Inside the Joint of Inflammatory Arthritis Patients: Handling and Processing of Synovial Tissue Biopsies for High Throughput Analysis.Frontiers in medicine · 2022Review
- Contribution of pathogenic T helper 1 and 17 cells to bursitis and tenosynovitis in polymyalgia rheumatica.Frontiers in immunology · 2022Article
- Inclusion of Synovial Tissue-Derived Characteristics in a Nomogram for the Prediction of Treatment Response in Treatment-Naive Rheumatoid Arthritis Patients.Arthritis & rheumatology (Hoboken, N.J.) · 2021Article
- A convolutional neural network with transfer learning for automatic discrimination between low and high-grade synovitis: a pilot study.Internal and emergency medicine · 2021Article
- Synovial biopsies in clinical practice and research: current developments and perspectives.Clinical rheumatology · 2021Review
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
24 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this global collaboration was to develop a consensual set of items for the analysis of synovial biopsies in clinical practice and translational research through the EULAR Synovitis Study Group (ESSG) and OMERACT Synovial Tissue Biopsy Group.
methodsParticipants were consulted through a modified Delphi method. Three sequential rounds occurred over 12 months. Members were sent a written questionnaire containing items divided into two parts. Items were identified and formulated based on a scoping review. The first part of the questionnaire referred to synovial biopsies in clinical practice including five subsections, and the second part to translational research with six subsections. Every participant was asked to score each item on a 5-point Likert scale. Items with a median score above 3.5 and a ≥ 70% agreement were selected for the next round. The last round was conducted orally at EULAR in June 2017.
resultsTwenty-seven participants from 19 centers were contacted by email. Twenty participants from 17 centers answered. Response rates for next rounds were 100%. For the first part relating to clinical practice, 20/44 items (45.5%) were selected. For the second part relating to translational research, 18/43 items (41.9%) were selected for the final set.
conclusionsWe herein propose a consensual set of analysis items to be used for synovial biopsies conducted in clinical practice and translational research.
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