Evidence map›Paper›PMID 30509299›Full record

ArticleParasites & vectors2018

Alternative insecticides for larval control of the dengue vector Aedes aegypti in Lao PDR: insecticide resistance and semi-field trial study.

Sébastien Marcombe, Somsanith Chonephetsarath, Phoutmany Thammavong, Paul T Brey

Open access · goldAbstract read
In one paragraph

Article in Parasites & vectors, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.

  1. Pooled it
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  9. Impact of SumiLarvParasites & vectors · 2024
    Article
  10. Article
  11. Worldwide Status of Insecticide Resistance ofJournal of arthropod-borne diseases · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sébastien MarcombeInstitut Pasteur du Laos, Ministry of Health, Vientiane, Lao PDR. s.marcombe@pasteur.la.
Somsanith ChonephetsarathInstitut Pasteur du Laos, Ministry of Health, Vientiane, Lao PDR.
Phoutmany ThammavongInstitut Pasteur du Laos, Ministry of Health, Vientiane, Lao PDR.
Paul T BreyInstitut Pasteur du Laos, Ministry of Health, Vientiane, Lao PDR.
Ministry of Health · LA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe mosquito Aedes aegypti is the primary vector of several arboviruses, such as dengue, chikungunya and Zika, and represents a major public health problem in Southeast Asia. In Laos, where dengue is reemerging, several Ae. aegypti populations from the capital Vientiane have shown resistance to the organophosphate temephos, a commonly-used larvicide for public health interventions.

methodsHere, we tested the insecticide susceptibility of a wild larval population of Ae. aegypti against Bacillus thuringiensis israelensis (Bti), diflubenzuron, pyriproxyfen and spinosad. Residual efficacies of Bti (VectobacWG®), diflubenzuron (Killmos®) and temephos (Abate®) were then evaluated under simulated field conditions against the wild Ae. aegypti population.

resultsThe larval bioassays showed that the wild Ae. aegypti strain was moderately resistant to temephos and spinosad (resistance ratio, RR < 5) and fully susceptible to the other insecticides (RR = 1). The simulated field trial bioassays showed that all of the insecticides tested remained above the WHO acceptable larvicide threshold after 28 weeks.

conclusionsThese results suggest that Bti and diflubenzuron may be promising alternative larvicides for controlling dengue vectors in water-storage containers in Laos, especially against Ae. aegypti populations, in which resistance to temephos has been detected.

Indexed as

AedesInsecticide ResistanceMosquito VectorsAnimalsBacillus thuringiensisDengueDrug CombinationsInsecticidesLaosLarvaMacrolidesMosquito ControlTemefosZika Virus InfectionDrug CombinationsInsecticidesMacrolidesspinosadTemefosAedes aegyptiBtiDengueDiflubenzuronIGRLaosPyriproxyfenSpinosadTemephosVector control

Identifiers

PMID30509299
PMCPMC6278129
OpenAlexW2902001641

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.