Evidence map›Paper›PMID 30509268›Full record

Trial reportRespiratory research2018

Use and inhalation technique of inhaled medication in patients with asthma and COPD: data from a randomized controlled trial.

Claudia Gregoriano, Thomas Dieterle, Anna-Lisa Breitenstein, Selina Dürr, Amanda Baum, Sabrina Maier, Isabelle Arnet, Kurt E Hersberger, Jörg D Leuppi

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Respiratory research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 4 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 4 syntheses or guidelines pooled it, 113 citations in OpenAlex.

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  19. Validation of an AI-Powered Smart Dry Powder Inhaler (RS01X) for Asthma and COPD in a Clinical Setting.International journal of chronic obstructive pulmonary disease · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Claudia GregorianoUniversity Clinic of Medicine, Cantonal Hospital Baselland, Rheinstrasse 26, CH - 4410, Liestal, Switzerland. claudia.gregoriano@ksbl.ch.
Thomas DieterleUniversity Clinic of Medicine, Cantonal Hospital Baselland, Rheinstrasse 26, CH - 4410, Liestal, Switzerland.
Anna-Lisa BreitensteinUniversity Clinic of Medicine, Cantonal Hospital Baselland, Rheinstrasse 26, CH - 4410, Liestal, Switzerland.
Selina DürrUniversity Clinic of Medicine, Cantonal Hospital Baselland, Rheinstrasse 26, CH - 4410, Liestal, Switzerland.
Amanda BaumUniversity Clinic of Medicine, Cantonal Hospital Baselland, Rheinstrasse 26, CH - 4410, Liestal, Switzerland.
Sabrina MaierUniversity Clinic of Medicine, Cantonal Hospital Baselland, Rheinstrasse 26, CH - 4410, Liestal, Switzerland.
Isabelle ArnetDepartment of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Kurt E HersbergerDepartment of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Jörg D LeuppiUniversity Clinic of Medicine, Cantonal Hospital Baselland, Rheinstrasse 26, CH - 4410, Liestal, Switzerland.
Psychiatry Baselland · CHUniversity of Basel · CH

Funding

AstraZeneca Schweiz (CH) NABoehringer Ingelheim Schweiz (CH) NAFreiwillige Akademische Gesellschaft NAGottfried und Julia Bangerter-Rhyner-Stiftung (CH) NALungenliga Schweiz (CH) NAMundipharma Schweiz (CH) NASchweizerische Akademie der Medizinischen Wissenschaften (CH) NA
6 · The paper itself

Abstract

backgroundThe burden of asthma and COPD among patients is high and people affected are frequently hospitalized due to exacerbations. There are numerous reasons for the lack of disease control in asthma and COPD patients. It is associated with non-adherence to guidelines on the part of the health care provider and with poor inhalation technique and/or non-adherence to the prescribed treatment plan by the patient. This study aims to present data on inhaler technique and its impact on quality of life (QoL) and symptom control in a typical population of patients with chronic lung disease from a randomized controlled trial on medication adherence.

methodsFor this cross-sectional analysis, 165 asthma and COPD patients were analyzed. Correct application of inhaler devices was tested using pre-defined checklists for each inhaler type. QoL and symptom control were investigated using COPD Assessment Test (CAT) and Asthma Control Test (ACT). Spirometry was used to measure forced vital capacity (FVC) and forced expiratory volume in one second (FEV

resultsOverall, incorrect inhalation technique ranged from 0 to 53% depending on the type of inhaler. COPD patients with incorrect device application had a higher CAT sum score compared to those with a correct device application (P = .02). Moreover, COPD patients with incorrect device application were more likely to suffer from cough (P = .03) and were more breathless while walking uphill or a flight of stairs (P = .02). While there was no significance found in asthma patients, COPD patients who used their devices correctly had a significantly better mean FEV

conclusionsCorrect inhalation of prescribed medication is associated with improved health status and lung function. These findings should encourage health professionals to provide instructions on correct inhalation technique and to regularly re-evaluate the patients' inhalation technique.

trial registrationClinicalTrials.gov: NCT0238672 , Registered 14 February 2014.

Indexed as

Medication AdherenceAdministration, InhalationAgedAsthmaBronchodilator AgentsCross-Sectional StudiesFemaleForced Expiratory VolumeHumansMaleMiddle AgedNebulizers and VaporizersPulmonary Disease, Chronic ObstructiveSingle-Blind MethodSpirometryBronchodilator AgentsAsthmaDry powder inhalersInhalation techniqueMetered dose inhalersPulmonary disease, chronic obstructiveQuality of life, lung function

Identifiers

PMID30509268
PMCPMC6276152
OpenAlexW2902788567

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.