ArticleMalaria journal2018
Spontaneous splenic rupture in Plasmodium knowlesi malaria.
Article in Malaria journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Article
- Where Sepsis Meets Haemorrhage: A Case Report of Spontaneous Splenic Rupture Following Perforated Diverticulitis.Case reports in surgery · 2026Article
- The Relationship Between Malaria and Pain: A Mini-Review.The American journal of tropical medicine and hygiene · 2025Review
- Malaria-Associated Spontaneous Splenic Rupture With Coagulopathy and Hemodynamic Compromise: A Case Report.Cureus · 2025Article
- Article
- Article
- Article
- Review
- Article
- Narrative Review of the Control and Prevention of Knowlesi Malaria.Tropical medicine and infectious disease · 2022Review
- Acute Colonic Pseudo-Obstruction in Severe Falciparum Malaria: A Case Report.Journal of medical cases · 2021Article
- A comparison of the clinical, laboratory and epidemiological features of two divergent subpopulations of Plasmodium knowlesi.Scientific reports · 2021Observational
- Surface area-to-volume ratio, not cellular viscoelasticity, is the major determinant of red blood cell traversal through small channels.Cellular microbiology · 2021Article
- Knowlesi malaria: Human risk factors, clinical spectrum, and pathophysiology.Advances in parasitology · 2021Article
- Lessons Learned for Pathogenesis, Immunology, and Disease of Erythrocytic Parasites:Frontiers in cellular and infection microbiology · 2021Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlasmodium knowlesi, a malaria parasite typically found in long-tailed and pig-tailed macaques, is the most common cause of human malaria in Malaysian Borneo. Infections in humans result in a spectrum of disease, including fatal outcomes. Spontaneous splenic rupture is a rare, but severe complication of malaria and has not been reported previously for knowlesi malaria. CASE PRESENTATION: A 46-year-old man presented with fever and acute surgical abdomen with concomitant P. knowlesi malaria infection at Kapit Hospital. He was in compensated shock upon arrival to the hospital. He had generalized abdominal tenderness, maximal at the epigastric region. Bedside focused abdominal ultrasonography revealed free fluid in the abdomen. He underwent emergency exploratory laparotomy in view of haemodynamic instability and worsening peritonism. Intraoperatively, haemoperitoneum and bleeding from the spleen was noted. Splenectomy was performed. Histopathological examination findings were suggestive of splenic rupture and presence of malarial pigment. Analysis of his blood sample by nested PCR assays confirmed P. knowlesi infection. The patient completed a course of anti-malarial treatment and recovered well post-operation.
conclusionsSpontaneous splenic rupture is a rare complication of malaria. This is the first reported case of splenic rupture in P. knowlesi malaria infection. Detection of such a complication requires high index of clinical suspicion and is extremely challenging in hospitals with limited resources.
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