Evidence map›Paper›PMID 30509139›Full record

ReviewExperimental biology and medicine (Maywood, N.J.)2018

Endocrine regulation of lung disease and inflammation.

Nathalie Fuentes, Patricia Silveyra

Open access · bronzeAbstract readReview
In one paragraph

Review in Experimental biology and medicine (Maywood, N.J.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Sex chromosomes and gonadal sex interactions in airway and immune responses to allergen challenge.American journal of physiology. Lung cellular and molecular physiology · 2026
    Article
  5. Sex, hormones, and lung health.Physiological reviews · 2026
    Review
  6. Article
  7. "Scripts" Don't Lie: Sex and Age Shape Blood Immune Gene Expression in Asthma.American journal of respiratory cell and molecular biology · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Sex and gender differences during the lung lifespan: unveiling a pivotal impact.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  16. Neuroendocrine contribution to sex-related variations in adverse air pollution health effects.Journal of toxicology and environmental health. Part B, Critical reviews · 2024
    Review
  17. Indoor air pollution and airway health.The Journal of allergy and clinical immunology · 2024
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nathalie Fuentes1 Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Patricia Silveyra1 Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.ORCID 0000-0001-7083-8915
Pennsylvania State University · US

Funding

Sex-specific mechanisms of ozone-induced acute lung inflammationK01HL133520 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SILVEYRA, PATRICIA · 2016 to 2019
$506k
Sex-Based Differences in Airway Structural Properties and Immune Response in HDM Challenged AnimalsR03HL141618 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SILVEYRA, PATRICIA · 2018 to 2019
$154k
NHLBI NIH HHS K01 HL133520NHLBI NIH HHS R03 HL141618
6 · The paper itself

Abstract

impact statementSex-differences in the incidence and severity of inflammatory lung diseases have been recognized for years. Women of reproductive age are more likely to suffer from chronic lung disease, with higher mortality rates than men. Physiological changes in hormone levels such as those occurring during the menstrual cycle, pregnancy, and menopause have been associated with lung function changes and asthma symptoms. Despite this, the roles of sex hormones in the mechanisms associated with lung diseases have not been fully elucidated. This review summarizes basic and clinical studies of sex hormones as potential modulators of lung function and inflammation. The information obtained from sex-specific research on lung physiology and pathology will potentially help in the development of sex-specific therapeutics for inflammatory lung disease that may account for the hormonal status of the patient.

Indexed as

Sex CharacteristicsAsthmaFemaleGonadal Steroid HormonesHumansInflammationMaleMenopauseMenstrual CyclePregnancyGonadal Steroid Hormonesasthmahormoneinflammationlung diseaselung immunitySex differences

Identifiers

PMID30509139
PMCPMC6348592
OpenAlexW2903234174

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.