Evidence map›Paper›PMID 30509137›Full record

ReviewExperimental biology and medicine (Maywood, N.J.)2019

Progress in synthesizing protocells.

O Duhan Toparlak, Sheref S Mansy

Abstract readReview
In one paragraph

Review in Experimental biology and medicine (Maywood, N.J.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Article
  3. Electrophysiological Characterization of Monoolein-Fatty Acid Bilayers.Langmuir : the ACS journal of surfaces and colloids · 2025
    Article
  4. Article
  5. Is Life Binary or Gradual?Life (Basel, Switzerland) · 2024
    Article
  6. Article
  7. Autonomic Integration in Nested Protocell Communities.Journal of the American Chemical Society · 2023
    Article
  8. Light energy transduction in liposome-based artificial cells.Frontiers in bioengineering and biotechnology · 2023
    Review
  9. Growth, replication and division enable evolution of coacervate protocells.Chemical communications (Cambridge, England) · 2022
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Prebiotic Reaction Networks in Water.Life (Basel, Switzerland) · 2020
    Review
  17. Review
  18. The difficult case of an RNA-only origin of life.Emerging topics in life sciences · 2019
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

O Duhan ToparlakCIBIO, University of Trento, Povo 38123, Italy.
Sheref S MansyCIBIO, University of Trento, Povo 38123, Italy.ORCID 0000-0003-2382-198X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

impact statementAdvances in the understanding of the biophysics of membranes, the nonenzymatic and enzymatic polymerization of RNA, and in the design of complex chemical reaction networks have led to a new, integrated way of viewing the shared chemistry needed to sustain life. Although a protocell capable of Darwinian evolution has yet to be built, the seemingly disparate pieces are beginning to fit together. At the very least, better cellular mimics are on the horizon that will likely teach us much about the physicochemical underpinnings of cellular life.

Indexed as

Artificial CellsCell CompartmentationLipidsNucleic AcidsPeptidesPolymersLipidsNucleic AcidsPeptidesPolymersminimal cellorigin of lifepeptidesprebiotic chemistryProtocellprotometabolismRNA worldvesicles

Identifiers

PMID30509137
PMCPMC6435886

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.