Evidence map›Paper›PMID 30508950›Full record

ArticleMedicine2018

Intralesional and subcutaneous application of Viscum album L. (European mistletoe) extract in cervical carcinoma in situ: A CARE compliant case report.

María Reynel, Yván Villegas, Helmut Kiene, Paul G Werthmann, Gunver S Kienle

Erratum issuedOpen access · goldAbstract readCase Reports
In one paragraph

Article in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Systematic analysis of mistletoe prescriptions in clinical studies.Journal of cancer research and clinical oncology · 2023
    Pooled it
  2. Article
  3. The Anti-Inflammatory Activity ofPlants (Basel, Switzerland) · 2023
    Review
  4. PluronicPharmaceutics · 2022
    Article
  5. Article
  6. Intralesional Agents in Dermatology: Pros and Cons.Journal of cutaneous and aesthetic surgery
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

María ReynelCentro Médico Antroposófico, Lima, Peru.
Yván VillegasCentro Médico Antroposófico, Lima, Peru.
Helmut KieneInstitute for Applied Epistemology and Medical Methodology at the University of Witten/Herdecke.
Paul G WerthmannInstitute for Applied Epistemology and Medical Methodology at the University of Witten/Herdecke.
Gunver S KienleInstitute for Applied Epistemology and Medical Methodology at the University of Witten/Herdecke.
University Medical Center Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleCarcinoma in situ (CIS) of the uterine cervix is a premalignant condition of squamous epithelium. The standard treatments are excision and ablation procedures; for women with positive margins, hysterectomy is recommended. PATIENT CONCERNS: A 47-year-old Peruvian woman with recurrent candidal vaginitis had been diagnosed with colpocervicitis and squamous metaplasia 8 years ago, which were not treated. DIAGNOSES: The patient was diagnosed with CIS after cervical conization procedure. She refused radical hysterectomy and opted for integrative medicine treatment.

interventionsShe was treated with intralesional and subcutaneous Viscum album L. extract (VAE) injections. VAE is a widely used herbal cancer treatment with cytotoxic, apoptogenic, and immunological effects, but it has not been investigated in cervical CIS. OUTCOMES: Ending month 5 of treatment, complete remission of cervical CIS was observed. The patient is still in remission after 30 months (until publication). LESSONS: This is the first report on complete remission of cervical CIS after intralesional and subcutaneous injection with VAE. Prospective studies should evaluate to what degree the treatment effect is reproducible.

Indexed as

Viscum albumAntineoplastic Agents, PhytogenicCarcinoma in SituCervix UteriFemaleHumansMiddle AgedPlant ProteinsRemission InductionTreatment RefusalUterine Cervical NeoplasmsAntineoplastic Agents, PhytogenicPlant Proteinsviscotoxin

Identifiers

PMID30508950
PMCPMC6283068
OpenAlexW2903048923

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.