ArticleJournal of psychiatric research2019
Brain mechanisms of stress and depression in coronary artery disease.
Article in Journal of psychiatric research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06740396 (Assessing the Prevalence and Severity of Depression Among Coronary Artery Diseases Patients in Baghdad Using the PHQ-9), which is not on this map. Cited by 8 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessing the Prevalence and Severity of Depression Among Coronary Artery Diseases Patients in Baghdad Using the PHQ-9: A Cross-Sectional Study
Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- The Heart-Brain Axis in the Context of Cardiovascular Disease.Physiology (Bethesda, Md.) · 2026Review
- Neuroimaging Links Between Heart Failure and Depression-A Narrative Review.Brain sciences · 2024Review
- Reward system activation improves recovery from acute myocardial infarction.Nature cardiovascular research · 2024Article
- Efficacy of the Integration of Traditional Chinese Medicine and Western Medicine in Coronary Heart Disease Comorbid with Anxiety and Depression: A Meta-Analysis.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Brain-heart connections in stress and cardiovascular disease: Implications for the cardiac patient.Atherosclerosis · 2021Review
- Peculiarities of Platelet Metabolism in Patients with Acute Coronary Syndrome with Anxiety-Depressive Disorders and Informativity of Enzymes in the Forecast of Development of Cardiovascular Complications.Pharmaceuticals (Basel, Switzerland) · 2020Article
- Confederates in the Attic: Posttraumatic Stress Disorder, Cardiovascular Disease, and the Return of Soldier's Heart.The Journal of nervous and mental disease · 2020Article
- Sex differences in brain activation patterns with mental stress in patients with coronary artery disease.Biology of sex differences · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionMajor depression is associated with an increased risk for and mortality from coronary artery disease (CAD), however the mechanisms by which this occurs are not clear. Depression, which is linked to stress, is associated with changes in brain areas involved in memory and the stress response, and it is likely that these regions play an important role in this increased risk. This study assessed the effects of stress on brain and cardiac function in patients with CAD with and without depression.
methodsCAD patients with (N = 17) and without (N = 21) major depression based on the Structured Clinical Interview for DSM-IV (DSM-IV) and/or a Hamilton Depression Scale score of nine or greater underwent imaging of the brain with high resolution positron emission tomography (HR-PET) and [O-15] water and imaging of the heart with single photon emission tomography (SPECT) and [Tc-99 m] sestamibi during mental stress (mental arithmetic) and control conditions.
resultsPatients with CAD and major depression showed increased parietal cortex activation and a relative failure of medial prefrontal/anterior cingulate activation during mental stress compared to CAD patients without depression. Depressed CAD patients with stress-induced myocardial ischemia, however, when compared to depressed CAD patients without showed increased activation in rostral portions of the anterior cingulate.
conclusionsThese findings are consistent with a role for brain areas implicated in stress and depression in the mechanism of increased risk for CAD morbidity and mortality in CAD patients with the diagnosis of major depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.