ArticleJournal of psychiatric research2019
Functional neural mechanisms of sensory phenomena in obsessive-compulsive disorder.
Article in Journal of psychiatric research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- The relationship between sensory phenomena and interoception across the obsessive-compulsive spectrum: a systematic review.BMC psychiatry · 2025Pooled it
- Randomized Controlled Trial of the Effects of High-Dose Ondansetron on Clinical Symptoms and Brain Connectivity in Obsessive-Compulsive and Tic Disorders.The American journal of psychiatry · 2025Trial
- Randomized trial of the efficacy of trial-based cognitive therapy for obsessive-compulsive disorder: preliminary findings.Trends in psychiatry and psychotherapy · 2023Trial
- Altered frontal and occipital cortical microstructure in obsessive-compulsive disorder - a multisite mega-analysis.Molecular psychiatry · 2026Article
- Differences in response inhibition between medication-free patients with obsessive-compulsive disorder with and without sensory phenomena.Journal of neuropsychology · 2026Article
- Earlier age at onset is associated with more severe sensory phenomena in drug-naive, comorbidity-free patients with obsessive-compulsive disorder.Frontiers in psychiatry · 2026Article
- Network Analysis of Sensory Phenomena and Obsessive-Compulsive Symptoms in OCD: A Multicenter Study.Depression and anxiety · 2026Article
- Widespread alterations of white matter integrity in medication-free obsessive-compulsive disorder.Translational psychiatry · 2025Article
- Reliability and validity of the Chinese version of The University of São Paulo Sensory Phenomena Scale in OCD patients.BMC psychiatry · 2025Article
- Network Analysis of Premonitory Urges, Tic Symptoms, Obsessive-Compulsive Symptoms, and Quality of Life in Drug-Naïve Children and Adolescents with Tic Disorder.Child psychiatry and human development · 2025Article
- Phenomenology of repetitive and restrictive behaviors and sensory phenomena in neurodevelopmental disorders: an exploratory study.BMC psychiatry · 2025Article
- Personalized non-invasive neuromodulation for sensory-based urge suppression in individuals with OCD: a proof-of-concept investigation.Frontiers in human neuroscience · 2025Article
- Identifying subgroups of urge suppression in Obsessive-Compulsive Disorder using machine learning.Journal of psychiatric research · 2024Article
- Sensory over-responsivity and orbitofrontal cortex connectivity in obsessive-compulsive disorder.Journal of affective disorders · 2024Article
- Lower synaptic density and its association with cognitive dysfunction in patients with obsessive-compulsive disorder.General psychiatry · 2024Article
- The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium.Molecular psychiatry · 2023Article
- Associations Between Suicidality and Interoception in Obsessive-Compulsive Disorder.Journal of obsessive-compulsive and related disorders · 2023Article
- Failures of Urge Suppression in Obsessive-Compulsive Disorder: Behavioral Modeling Using a Blink Suppression Task.Journal of obsessive-compulsive and related disorders · 2023Article
- Abnormal resting-state functional connectivity of the insula in medication-free patients with obsessive-compulsive disorder.BMC psychiatry · 2022Article
- Aberrant cortico-striatal white matter connectivity and associated subregional microstructure of the striatum in obsessive-compulsive disorder.Molecular psychiatry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Sensory phenomena (SP) are aversive or uncomfortable sensations that accompany and/or drive repetitive behaviors in obsessive-compulsive disorder (OCD). Although SP are associated with significant distress and may respond less well to standard treatments than harm-related obsessions, little is known about their underlying neurobiology. The present study used functional magnetic resonance imaging (fMRI) to measure brain functioning related to severity of SP during a "body-focused" videos task designed to elicit activation in sensorimotor brain regions. Regression analysis examined the relationship between severity of SP and activation during task using permutation analysis, cluster-level corrected for multiple comparisons (family-wise error rate p < 0.05). The distribution of SP severity was not significantly different from normal, with both high- and low-severity scores represented in the OCD sample. Severity of SP was not correlated with other clinical symptoms in OCD including general anxiety, depression, or harm avoidance. When viewing body-focused videos, patients with greater severity of SP showed increased activity in the mid-posterior insula, a relationship that remained significant when controlling for other clinical symptoms, medication status, and comorbidities. At uncorrected thresholds, SP severity was also positively related to somatosensory, mid orbitofrontal, and lateral prefrontal cortical activity. These data suggest that SP in OCD are dissociable from other symptoms in the disorder and related to hyperactivation of the insula. Future work examining neural mechanisms of SP across different disorders (tics, trichotillomania) as well as with other imaging modalities will be needed to further understand the neurobiology of these impairing symptoms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.