Evidence map›Paper›PMID 30508699›Full record

ArticleRedox biology2019

Therapeutic potential of the mitochondria-targeted antioxidant MitoQ in mitochondrial-ROS induced sensorineural hearing loss caused by Idh2 deficiency.

Ye-Ri Kim, Jeong-In Baek, Sung Hwan Kim, Min-A Kim, Byeonghyeon Lee, Nari Ryu, Kyung-Hee Kim, Deok-Gyun Choi, Hye-Min Kim, Michael P Murphy and 6 more

Open access · goldAbstract read
In one paragraph

Article in Redox biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 61 citations in OpenAlex.

  1. Review
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  3. Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  12. Hesperidin activates Nrf2 to protect cochlear hair cells from cisplatin-induced damage.Redox report : communications in free radical research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Ye-Ri KimDepartment of Biology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea; School of Life Sciences, KNU Creative BioResearch Group (BK21 Plus Project), Kyungpook National University, Daegu, Republic of Korea.
Jeong-In BaekDepartment of Aroma-Applied Industry, College of Herbal Bio-industry, Daegu Haany University, Gyeongsan, Republic of Korea.
Sung Hwan KimDepartment of Biology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea; School of Life Sciences, KNU Creative BioResearch Group (BK21 Plus Project), Kyungpook National University, Daegu, Republic of Korea.
Min-A KimDepartment of Biology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea; School of Life Sciences, KNU Creative BioResearch Group (BK21 Plus Project), Kyungpook National University, Daegu, Republic of Korea.
Byeonghyeon LeeDepartment of Biology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea; School of Life Sciences, KNU Creative BioResearch Group (BK21 Plus Project), Kyungpook National University, Daegu, Republic of Korea.
Nari RyuDepartment of Biology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea; School of Life Sciences, KNU Creative BioResearch Group (BK21 Plus Project), Kyungpook National University, Daegu, Republic of Korea.
Kyung-Hee KimDepartment of Biology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea; School of Life Sciences, KNU Creative BioResearch Group (BK21 Plus Project), Kyungpook National University, Daegu, Republic of Korea.
Deok-Gyun ChoiDepartment of Biology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea.
Hye-Min KimDepartment of Biology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea; School of Life Sciences, KNU Creative BioResearch Group (BK21 Plus Project), Kyungpook National University, Daegu, Republic of Korea.
Michael P MurphyMedical Research Council (MRC)-Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
Greg MacphersonAntipodean Pharmaceuticals Inc, L2 14 Viaduct Harbour Rd, Auckland, New Zealand.
Yeon-Sik ChooDepartment of Biology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea.
Jinwoong BokDepartment of Anatomy, Yonsei University College of Medicine, Seoul, Republic of Korea; BK21PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Kyu-Yup LeeDepartment of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. Electronic address: kylee@knu.ac.kr.
Jeen-Woo ParkSchool of Life Sciences, KNU Creative BioResearch Group (BK21 Plus Project), Kyungpook National University, Daegu, Republic of Korea; Department of Biochemistry, School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu 41566, Republic of Korea. Electronic address: parkjw@knu.ac.kr.
Un-Kyung KimDepartment of Biology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea; School of Life Sciences, KNU Creative BioResearch Group (BK21 Plus Project), Kyungpook National University, Daegu, Republic of Korea. Electronic address: kimuk@knu.ac.kr.
Kyungpook National University · KRDaegu Haany University · KRPharmac · NZUniversity of Cambridge · GBYonsei University · KR

Funding

Medical Research Council MC_UU_00015/3
6 · The paper itself

Abstract

Mitochondrial NADP

Indexed as

AnimalsApoptosisBiomarkersDisease Models, AnimalFluorescent Antibody TechniqueHair Cells, AuditoryHearing Loss, SensorineuralHomozygoteImmunohistochemistryIsocitrate DehydrogenaseMiceMice, KnockoutMitochondriaOrganophosphorus CompoundsOxidation-ReductionOxidative StressBiomarkersIsocitrate Dehydrogenaseisocitrate dehydrogenase 2, mousemitoquinoneOrganophosphorus CompoundsReactive Oxygen SpeciesUbiquinoneAntioxidantHearing lossIdh2MitoQNADP(+)ROS

Identifiers

PMID30508699
PMCPMC6279977
OpenAlexW2901085576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.