Evidence map›Paper›PMID 30508396›Full record

ArticleAmerican journal of respiratory cell and molecular biology2019

Hyperoxia-induced Cellular Senescence in Fetal Airway Smooth Muscle Cells.

Pavan Parikh, Rodney D Britt, Logan J Manlove, Sarah A Wicher, Anne Roesler, Jovanka Ravix, Jacob Teske, Michael A Thompson, Gary C Sieck, James L Kirkland and 4 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 76 citations in OpenAlex.

  1. Trial
  2. Hyperoxia and iron homeostasis in developing human airway smooth muscle.American journal of physiology. Lung cellular and molecular physiology · 2026
    Article
  3. Review
  4. Article
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  13. Review
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  17. Article
  18. Senotherapy for chronic lung disease.Pharmacological reviews · 2025
    Review
  19. Review
  20. Senescence of lung mesenchymal stem cells of preterm infants by cyclic stretch and hyperoxia via p21.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Pavan Parikh1 Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology.
Rodney D Britt2 Center for Perinatal Research, Research Institute at Nationwide Children's Hospital, Columbus, Ohio; and.
Logan J Manlove4 Department of Anesthesiology and Perioperative Medicine.
Sarah A Wicher4 Department of Anesthesiology and Perioperative Medicine.
Anne Roesler4 Department of Anesthesiology and Perioperative Medicine.
Jovanka Ravix4 Department of Anesthesiology and Perioperative Medicine.
Jacob Teske4 Department of Anesthesiology and Perioperative Medicine.
Michael A Thompson4 Department of Anesthesiology and Perioperative Medicine.
Gary C Sieck5 Department of Physiology and Biomedical Engineering.
James L Kirkland5 Department of Physiology and Biomedical Engineering.
Nathan LeBrasseur5 Department of Physiology and Biomedical Engineering.
Daniel J Tschumperlin5 Department of Physiology and Biomedical Engineering.
Christina M Pabelick4 Department of Anesthesiology and Perioperative Medicine.
Y S Prakash4 Department of Anesthesiology and Perioperative Medicine.
Association of Perioperative Registered Nurses · USMayo Clinic · USInstitute of Physiology and Basic Medicine · RUNationwide Children's Hospital · USPain and Rehabilitation Medicine · USSociety for Maternal-Fetal Medicine · US

Funding

Mayo Clinic Center for Clinical and Translational Science (CCaTS UL1 Supplement - Dr. Timothy Curry)UL1TR002377 · NCATS · MAYO CLINIC ROCHESTER · PI VESNA D GAROVIC · 2017 to 2026
$78.4M
NEURAL REGULATION OF AIRWAYS DURING POSTNATAL MATURATIONR01HL056470 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S. · 1996 to 2025
$10.5M
Effect of Aging on Preadipocyte DifferentiationR37AG013925 · NIA · MAYO CLINIC ROCHESTER · PI KIRKLAND, JAMES L. · 2016 to 2025
$6.6M
Effect of Aging on Preadipocyte DifferentiationR01AG013925 · NIA · MAYO CLINIC ROCHESTER · PI KIRKLAND, JAMES L. · 1997 to 2012
$3.7M
Understanding CPAP Effects in the Developing AirwayR01HL138402 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI MACFARLANE, PETER · 2017 to 2020
$2.5M
NCATS NIH HHS UL1 TR002377NHLBI NIH HHS R01 HL056470NHLBI NIH HHS R01 HL138402NIA NIH HHS R01 AG013925NIA NIH HHS R37 AG013925
6 · The paper itself

Abstract

Supplemental O

Indexed as

Cellular SenescenceBiomarkersCell CycleCytokinesDasatinibDNA DamageEtoposideExtracellular MatrixExtracellular Matrix ProteinsFetusHumansHyperoxiaInflammation MediatorsLungModels, BiologicalMyocytes, Smooth MuscleBiomarkersCytokinesDasatinibEtoposideExtracellular Matrix ProteinsInflammation MediatorsQuercetinasthmaneonatalreactive airway diseasesenescence

Identifiers

PMID30508396
PMCPMC6604224
OpenAlexW2902997102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.