Evidence map›Paper›PMID 30508377›Full record

ArticleACS nano2018

Quantitative Imaging of Tumor-Associated Macrophages and Their Response to Therapy Using

Hye-Yeong Kim, Ran Li, Thomas S C Ng, Gabriel Courties, Christopher Blake Rodell, Mark Prytyskach, Rainer H Kohler, Mikael J Pittet, Matthias Nahrendorf, Ralph Weissleder and 1 more

Abstract read
In one paragraph

Article in ACS nano, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 1 synthesis or guideline pooled it, 140 citations in OpenAlex.

  1. Pooled it
  2. First-in-Human Study of the Carbohydrate NanoparticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Trial
  3. Article
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  5. Article
  6. Pharmaceuticals (Basel, Switzerland) · 2026
    Review
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  9. Article
  10. Article
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  12. Article
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  15. Article
  16. Scission-Enhanced Molecular Imaging (SEMI).Bioconjugate chemistry · 2024
    Article
  17. Review
  18. Review
  19. Review
  20. Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Hye-Yeong KimCenter for Systems Biology , Massachusetts General Hospital Research Institute , Boston , Massachusetts 02114 , United States.ORCID 0000-0001-9081-8487
Ran LiCenter for Systems Biology , Massachusetts General Hospital Research Institute , Boston , Massachusetts 02114 , United States.ORCID 0000-0002-8537-8824
Thomas S C NgCenter for Systems Biology , Massachusetts General Hospital Research Institute , Boston , Massachusetts 02114 , United States.
Gabriel CourtiesCenter for Systems Biology , Massachusetts General Hospital Research Institute , Boston , Massachusetts 02114 , United States.ORCID 0000-0002-0003-7407
Christopher Blake RodellCenter for Systems Biology , Massachusetts General Hospital Research Institute , Boston , Massachusetts 02114 , United States.ORCID 0000-0003-2168-0802
Mark PrytyskachCenter for Systems Biology , Massachusetts General Hospital Research Institute , Boston , Massachusetts 02114 , United States.ORCID 0000-0001-7070-8993
Rainer H KohlerCenter for Systems Biology , Massachusetts General Hospital Research Institute , Boston , Massachusetts 02114 , United States.ORCID 0000-0001-6269-6590
Mikael J PittetCenter for Systems Biology , Massachusetts General Hospital Research Institute , Boston , Massachusetts 02114 , United States.ORCID 0000-0002-2060-4691
Matthias NahrendorfCenter for Systems Biology , Massachusetts General Hospital Research Institute , Boston , Massachusetts 02114 , United States.
Ralph WeisslederCenter for Systems Biology , Massachusetts General Hospital Research Institute , Boston , Massachusetts 02114 , United States.ORCID 0000-0003-0828-4143
Miles A MillerCenter for Systems Biology , Massachusetts General Hospital Research Institute , Boston , Massachusetts 02114 , United States.ORCID 0000-0001-7638-8898
Massachusetts General Hospital · USHarvard University · US

Funding

Training Grant in Molecular Imaging Research (MGH/HMS)T32CA079443 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2000 to 2025
$10.1M
Imaging of nanotherapeutic drug actionU01CA206997 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2017 to 2021
$2.9M
Quantitative nanoparticle imaging of macrophagesR01HL131495 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NAHRENDORF, MATTHIAS, WEISSLEDER, MD, PHD, RALPH · 2017 to 2020
$2.7M
Imaging tumor associated macrophage (TAM) functionR01CA206890 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI PITTET, MIKAEL, WEISSLEDER, MD, PHD, RALPH · 2017 to 2021
$1.9M
Single Cell In Vivo Imaging Technology to Analyze Taxane Nano Formulations in Breast CancerR00CA207744 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI MILLER, MILES A · 2018 to 2020
$747k
Single Cell In Vivo Imaging Technology to Analyze Taxane Nano Formulations in Breast CancerK99CA207744 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI MILLER, MILES A · 2016 to 2017
$359k
NCI NIH HHS K99 CA207744NCI NIH HHS R00 CA207744NCI NIH HHS R01 CA206890NCI NIH HHS T32 CA079443NCI NIH HHS U01 CA206997NHLBI NIH HHS R01 HL131495
6 · The paper itself

Abstract

Tumor-associated macrophages (TAMs) are widely implicated in cancer progression, and TAM levels can influence drug responses, particularly to immunotherapy and nanomedicines. However, it has been difficult to quantify total TAM numbers and their dynamic spatiotemporal distribution in a non-invasive and translationally relevant manner. Here, we address this need by developing a pharmacokinetically optimized,

Indexed as

Isotope LabelingAnimalsAntibiotics, AntineoplasticCopper RadioisotopesDoxorubicinDrug Screening Assays, AntitumorFemaleGlucansLung NeoplasmsMacrophagesMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred NODMice, KnockoutNanoparticlesAntibiotics, AntineoplasticCopper-64Copper RadioisotopesDoxorubicinGlucansEPR effectimmunogenic chemotherapymyeloid infiltrationpersonalized medicineprognostic biomarkertumor microenvironment

Identifiers

PMID30508377
PMCPMC6482841
OpenAlexW2902453211

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.