ArticlePLoS pathogens2018
Tissue tropisms opt for transmissible reassortants during avian and swine influenza A virus co-infection in swine.
Article in PLoS pathogens, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Genetic and biological characterization of a reassortant H3N2 swine influenza virus isolated in China with internal genes from the 2009 pandemic H1N1.BMC microbiology · 2026Article
- Applications and Considerations of Artificial Intelligence in Veterinary Sciences: A Narrative Review.Veterinary medicine and science · 2025Review
- Article
- Vaccination decreases the risk of influenza A virus reassortment but not genetic variation in pigs.eLife · 2022Article
- Coinfection of Chickens with H9N2 and H7N9 Avian Influenza Viruses Leads to Emergence of Reassortant H9N9 Virus with Increased Fitness for Poultry and a Zoonotic Potential.Journal of virology · 2022Article
- Article
- Limited onward transmission potential of reassortment genotypes from chickens co-infected with H9N2 and H7N9 avian influenza viruses.Emerging microbes & infections · 2021Article
- Innate Antiviral Cytokine Response to Swine Influenza Virus by Swine Respiratory Epithelial Cells.Journal of virology · 2021Article
- Animal coronaviruses and SARS-CoV-2.Transboundary and emerging diseases · 2021Review
- Transmission of infectious viruses in the natural setting at human-animal interface.Current research in virological science · 2021Article
- Review
- Tissue Tropisms of Avian Influenza A Viruses Affect Their Spillovers from Wild Birds to Pigs.Journal of virology · 2020Article
- A method for the unbiased quantification of reassortment in segmented viruses.Journal of virological methods · 2020Article
- Ethanol Extract ofViruses · 2020Article
- Animal models for the risk assessment of viral pandemic potential.Laboratory animal research · 2020Review
- Improving risk assessment of the emergence of novel influenza A viruses by incorporating environmental surveillance.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
Abstract
Genetic reassortment between influenza A viruses (IAVs) facilitate emergence of pandemic strains, and swine are proposed as a "mixing vessel" for generating reassortants of avian and mammalian IAVs that could be of risk to mammals, including humans. However, how a transmissible reassortant emerges in swine are not well understood. Genomic analyses of 571 isolates recovered from nasal wash samples and respiratory tract tissues of a group of co-housed pigs (influenza-seronegative, avian H1N1 IAV-infected, and swine H3N2 IAV-infected pigs) identified 30 distinct genotypes of reassortants. Viruses recovered from lower respiratory tract tissues had the largest genomic diversity, and those recovered from turbinates and nasal wash fluids had the least. Reassortants from lower respiratory tracts had the largest variations in growth kinetics in respiratory tract epithelial cells, and the cold temperature in swine nasal cells seemed to select the type of reassortant viruses shed by the pigs. One reassortant in nasal wash samples was consistently identified in upper, middle, and lower respiratory tract tissues, and it was confirmed to be transmitted efficiently between pigs. Study findings suggest that, during mixed infections of avian and swine IAVs, genetic reassortments are likely to occur in the lower respiratory track, and tissue tropism is an important factor selecting for a transmissible reassortant.
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