ArticleeLife2018
Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Differential expression of members of SOX family of transcription factors in failing human hearts.Translational research : the journal of laboratory and clinical medicine · 2022Pooled it
- The interplay between supercoiling and DNA modifying enzymes at the single-molecule level.Scientific reports · 2026Article
- Elucidating the roles of microRNA-103a-3p in trophoblast invasion and SOX4-mediated extravillous differentiation induced by activin A.Cell death & disease · 2026Article
- SOX4-STAT6-MTHFD2 axis drives hepatocellular carcinoma progression and treatment resistance.Cell death & disease · 2026Article
- Stem cell activation in organ culture reveals novel transcriptional programs underlying metabolic, fibrotic, vascular, and immune dysregulation in uterine leiomyomas.Frontiers in cell and developmental biology · 2026Article
- Advancing Intervertebral Disc Biology via Omics: Implications for Nucleus Pulposus Progenitor Cell-Based Regeneration.JOR spine · 2025Review
- Article
- SOX4 reprograms fatty acid metabolism through the CHREBP to inhibit ferroptosis in hepatocellular carcinoma.Cell death discovery · 2025Article
- ADAMTS16 drives epithelial-mesenchymal transition and metastasis through a feedback loop upon TGF-β1 activation in lung adenocarcinoma.Cell death & disease · 2024Article
- SOX4-BMI1 axis promotes non-small cell lung cancer progression and facilitates angiogenesis by suppressing ZNF24.Cell death & disease · 2024Article
- KIS, a target of SOX4, regulates the ID1-mediated enhancement of β-catenin to facilitate lung adenocarcinoma cell proliferation and metastasis.Journal of cancer research and clinical oncology · 2024Article
- Targeting SMAD-Dependent Signaling: Considerations in Epithelial and Mesenchymal Solid Tumors.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Single-cell sequencing dissects the transcriptional identity of activated fibroblasts and identifies novel persistent distal tubular injury patterns in kidney fibrosis.Scientific reports · 2024Article
- Desmoglein-2 expression is an independent predictor of poor prognosis patients with multiple myeloma.Molecular oncology · 2022Article
- Regulation of a progenitor gene program by SOX4 is essential for mammary tumor proliferation.Oncogene · 2021Article
- Multi-Omics Analysis ofJournal of personalized medicine · 2021Article
- Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing.JCI insight · 2021Article
- The genomic architecture of metastasis in breast cancer: focus on mechanistic aspects, signalling pathways and therapeutic strategies.Medical oncology (Northwood, London, England) · 2021Review
- The effect of SOX4 gene 3'UTR polymorphisms on osteoporosis.Journal of orthopaedic surgery and research · 2021Article
- Potential of peptide-engineered exosomes with overexpressed miR-92b-3p in anti-angiogenic therapy of ovarian cancer.Clinical and translational medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 4 institutions in 2 countries.
Stephin J Vervoort *Department of Cell Biology, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
Olivier G de Jong *Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands.
M Guy Roukens *Department of Cell Biology, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
Cynthia L Frederiks *Department of Cell Biology, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
Jeroen F VermeulenDepartment of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
Ana Rita LourençoDepartment of Cell Biology, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
Laura BellaDepartment of Surgery and Cancer, Imperial Centre for Translational and Experimental Medicine, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom.
Ana Tufegdzic VidakovicCancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge, United Kingdom.
José L SandovalCancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge, United Kingdom.
Cathy MoelansDepartment of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
Miranda van AmersfoortDepartment of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
Margaret J DallmanDepartment of Life Sciences, Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom.
Alejandra BrunaCancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge, United Kingdom.
Carlos CaldasCancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge, United Kingdom.
Edward NieuwenhuisDivision of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
Elsken van der WallCancer Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Patrick DerksenDepartment of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
Paul van DiestDepartment of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
Marianne C VerhaarDepartment of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands.
Eric W-F LamDepartment of Surgery and Cancer, Imperial Centre for Translational and Experimental Medicine, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom.
Michal MokryDivision of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
Paul J CofferDepartment of Cell Biology, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID 0000-0001-8775-1939
University Medical Center Utrecht · NLCancer Research UK Cambridge Center · GBHammersmith Hospital · GBImperial College London · GB
Funding
Breast Cancer Now 2012MayPR070Breast Cancer Now 2012MAYPR070Breast Cancer Now 2012NovPhD016Breast Cancer Now 2012NOVPHD016Cancer Research UK 12011Cancer Research UK 16942Cancer Research UK A12011Cancer Research UK C37/A12011Cancer Research UK C37/A18784Medical Research Council MR/N012097/1
Abstract
The expression of the transcription factor
Indexed as
Transcription, GeneticAnimalsBreast NeoplasmsChromatinCulture Media, ConditionedEndothelin-1Epigenesis, GeneticEpithelial CellsFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGene Regulatory NetworksHEK293 CellsHumansNeoplasm MetastasisNeovascularization, PathologicChromatinCulture Media, ConditionedEndothelin-1RNA, MessengerSOXC Transcription FactorsTrans-ActivatorsAngiogenesisbreast cancercancer biologycell biologyEDN1Endothelin-1humanmouseSOX4tumor biologyzebrafish
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.