Evidence map›Paper›PMID 30507363›Full record

SynthesisInternational journal of stroke : official journal of the International Stroke Society2019

How do neurologists diagnose transient ischemic attack: A systematic review.

Tess Fitzpatrick, Sophia Gocan, Chu Q Wang, Candyce Hamel, Aline Bourgoin, Dar Dowlatshahi, Grant Stotts, Michel Shamy

Registry-linked trialOpen access · hybridAbstract readSystematic Review
In one paragraph

Synthesis in International journal of stroke : official journal of the International Stroke Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05620966 (Evaluating the Feasibility of a Portable Electroencephalogram Device in Diagnosing Transient Ischemic Attack and Stroke), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05620966 completednot on this mapstarted 2022, after this paper: background citation

Evaluating the Feasibility of a Portable Electroencephalogram Device in Diagnosing Transient Ischemic Attack and Stroke

TypeobservationalSponsorSunnybrook Health Sciences CentreRan2022 to 2022Enrolled21ConditionsStroke, Transient Ischemic AttackArmsCGX Systems Quick-20m
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Systematic review of CMTX1 patients with episodic neurological dysfunction.Annals of clinical and translational neurology · 2021
    Pooled it
  2. Article
  3. [The SCD diagnostic strategy, procedure and pathway for episodic vestibular syndrome].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Transient ischemic attack and minor stroke: diagnosis, risk stratification and management.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2022
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Dysphasia is associated with diffusion-weighted MRI abnormalities in patients with transient neurological symptoms.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Article
  14. Article
  15. Saving bones without risking brain-bisphosphonates and risk of stroke: matched case-control study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Tess Fitzpatrick1 Department of Medicine, Division of Neurology, The Ottawa Hospital, Ottawa, Canada.ORCID 0000-0003-4087-4653
Sophia Gocan1 Department of Medicine, Division of Neurology, The Ottawa Hospital, Ottawa, Canada.ORCID 0000-0001-5633-3304
Chu Q Wang2 The Ottawa Hospital Research Institute, Ottawa, Canada.ORCID 0000-0002-3233-8669
Candyce Hamel2 The Ottawa Hospital Research Institute, Ottawa, Canada.ORCID 0000-0002-5871-2137
Aline Bourgoin1 Department of Medicine, Division of Neurology, The Ottawa Hospital, Ottawa, Canada.
Dar Dowlatshahi1 Department of Medicine, Division of Neurology, The Ottawa Hospital, Ottawa, Canada.
Grant Stotts1 Department of Medicine, Division of Neurology, The Ottawa Hospital, Ottawa, Canada.
Michel Shamy1 Department of Medicine, Division of Neurology, The Ottawa Hospital, Ottawa, Canada.
Ottawa Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIdentifying and treating patients with transient ischemic attack is an effective means of preventing stroke. However, making this diagnosis can be challenging, and over a third of patients referred to stroke prevention clinic are ultimately found to have alternate diagnoses.

aimsWe performed a systematic review to determine how neurologists diagnose transient ischemic attack. SUMMARY OF REVIEW: A systematic literature search was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines using MEDLINE, Embase, and the Cochrane Library databases. Publications eligible for inclusion were those that included information on the demographic or clinical features neurologists use to diagnose transient ischemic attacks or transient ischemic attack-mimics. Of 1666 citations, 210 abstracts were selected for full-text screening and 80 publications were ultimately deemed eligible for inclusion. Neurologists were more likely to diagnose transient ischemic attack based on clinical features including negative symptoms or speech deficits. Patients with positive symptoms, altered level of consciousness, or the presence of nonfocal symptoms such as confusion or amnesia were more likely to be diagnosed with transient ischemic attack-mimic. Neurologists commonly include mode of onset (i.e. sudden versus gradual), recurrence of attacks, and localizability of symptoms to a distinct vascular territory in the diagnostic decision-making process. Transient ischemic attack diagnosis was more commonly associated with advanced age, preexisting hypertension, atrial fibrillation, and other vascular risk factors.

conclusionsNeurologists rely on certain clinical and demographic features to distinguish transient ischemic attacks from mimics, which are not currently reflected in widely used risk scores. Clarifying how neurologists diagnose transient ischemic attack may help frontline clinicians to better select patients for referral to stroke prevention clinics.

Indexed as

Clinical Decision-MakingNeurologistsAtrial FibrillationCanadaDiagnosis, DifferentialHumansHypertensionIschemic Attack, TransientRisk FactorsStrokedecision analysisstrokestroke mimicstroke preventionTransient ischemic attack

Identifiers

PMID30507363
PMCPMC6604401
OpenAlexW2902206459

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.