Evidence map›Paper›PMID 30506941›Full record

ArticleGlia2019

Augmented astrocyte microdomain Ca

Juan Ramiro Diaz, Ki Jung Kim, Michael W Brands, Jessica A Filosa

Abstract read
In one paragraph

Article in Glia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Neurovascular coupling and CONature communications · 2024
    Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Astrocytic TRPV4 Channels and Their Role in Brain Ischemia.International journal of molecular sciences · 2023
    Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Juan Ramiro DiazDepartment of Physiology, Augusta University, Augusta, Georgia.
Ki Jung KimDepartment of Physiology, Augusta University, Augusta, Georgia.
Michael W BrandsDepartment of Physiology, Augusta University, Augusta, Georgia.
Jessica A FilosaDepartment of Physiology, Augusta University, Augusta, Georgia.ORCID 0000-0001-7536-2039
Augusta University · US

Funding

Signals and targets underlying mechanisms for neurovascular coupling in the brainR01HL089067 · NHLBI · UNIVERSITY OF CINCINNATI · PI FILOSA, JESSICA A · 2007 to 2017
$3.2M
Clinically unscreened vasculo-glial-neuronal coupling is critical for physiological brain functionR01NS097818 · NINDS · AUGUSTA UNIVERSITY · PI FILOSA, JESSICA A · 2017 to 2021
$1.8M
NHLBI NIH HHS R01 HL089067NHLBI NIH HHS R01 HL089067-02NHLBI NIH HHS R01HL089067-02NINDS NIH HHS 1R01NS082521-01NINDS NIH HHS R01 NS097818
6 · The paper itself

Abstract

Hypertension is an important contributor to cognitive decline but the underlying mechanisms are unknown. Although much focus has been placed on the effect of hypertension on vascular function, less is understood of its effects on nonvascular cells. Because astrocytes and parenchymal arterioles (PA) form a functional unit (neurovascular unit), we tested the hypothesis that hypertension-induced changes in PA tone concomitantly increases astrocyte Ca

Indexed as

Angiotensin IIAnimalsArteriolesAstrocytesBrainCalciumCalcium SignalingHypertensionMaleMiceParenchymal TissueTRPV Cation ChannelsAngiotensin IICalciumTRPV Cation Channelsastrocyteshypertensionmyogenic toneneurovascular unitparenchymal arterioletwo to five subject codes

Identifiers

PMID30506941
PMCPMC7033753
OpenAlexW2902014698

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.