Evidence map›Paper›PMID 30506877›Full record

ArticleMagnetic resonance in medicine2019

Real-time simultaneous shim and motion measurement and correction in glycoCEST MRI using double volumetric navigators (DvNavs).

Gizeaddis L Simegn, Andre J W Van der Kouwe, Frances C Robertson, Ernesta M Meintjes, Ali Alhamud

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Dynamic glucose-enhanced MRI in brain tumors.Magma (New York, N.Y.) · 2026
    Review
  3. Article
  4. Prospective motion correction forMagnetic resonance in medicine · 2025
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  5. Review
  6. Article
  7. Article
  8. Review
  9. Biogenic Imaging Contrast Agents.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  10. Article
  11. Article
  12. BTomography (Ann Arbor, Mich.) · 2022
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Magnetic resonance imaging of glycogen using its magnetic coupling with water.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Gizeaddis L SimegnUCT Medical Imaging Research Unit, Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Cape Town, South Africa.
Andre J W Van der KouweUCT Medical Imaging Research Unit, Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Cape Town, South Africa.
Frances C RobertsonUCT Medical Imaging Research Unit, Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Cape Town, South Africa.
Ernesta M MeintjesUCT Medical Imaging Research Unit, Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Cape Town, South Africa.
Ali AlhamudUCT Medical Imaging Research Unit, Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Cape Town, South Africa.
University of Cape Town · ZACape Town Science Centre · ZA

Funding

Longitudinal Neuroimaging and Cognitive Study of HIV-Infected ChildrenR01HD071664 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI LAUGHTON, BARBARA, MEINTJES, ERNESTA MARIA · 2011 to 2015
$2.4M
Neonatal imaging as an early marker of neurodevelopment and predictor of cognitive performance in infants exposed to HIV and ART in utero and perinatallyR01HD085813 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI LAUGHTON, BARBARA, MEINTJES, ERNESTA MARIA · 2016 to 2020
$2.3M
Longitudinal, multimodal analysis of HIV and ART effects on brain metabolism, structure and connectivity in young childrenR21MH108346 · NIMH · UNIVERSITY OF CAPE TOWN · PI BISWAL, BHARAT BHUSAN, MEINTJES, ERNESTA MARIA · 2015 to 2016
$298k
Department of Science and Technology and National Research Foundation of South Africa; NRF Thuthuka TTK 150612119380Netherlands Initiative for Capacity development in Higher Education-NICHE/ETH/247NICHD NIH HHS R01 HD071664NICHD NIH HHS R01 HD085813NIH HHS R01HD071664NIH HHS R01HD085813NIH HHS R21MH108346NIMH NIH HHS R21 MH108346
6 · The paper itself

Abstract

purposeCEST MRI allows for indirect detection of molecules with exchangeable protons, measured as a reduction in water signal because of continuous transfer of saturated protons. CEST requires saturation pulses on the order of a second, as well as repeated acquisitions at different offset frequencies. The resulting extended scan time makes CEST susceptible to subject motion, which introduces field inhomogeneity, shifting offset frequencies and causing distortions in CEST spectra that resemble true CEST effects. This is a particular problem for molecules that resonate close to water, such as hydroxyl group in glycogen. To address this, a technique for real-time measurement and correction of motion and field inhomogeneity is proposed.

methodsA CEST sequence was modified to include double volumetric navigators (DvNavs) for real-time simultaneous motion and shim correction. Phantom tests were conducted to investigate the effects of motion and shim changes on CEST quantification and to validate the accuracy of DvNav motion and shim estimates. To evaluate DvNav shim and motion correction in vivo, acquisitions including 5 experimental conditions were performed in the calf muscle of 2 volunteers.

resultsPhantom data show that DvNav-CEST accurately estimates frequency and linear gradient changes because of motion and corrects resulting image distortions. In addition, DvNav-CEST improves CEST quantification in vivo in the presence of motion.

conclusionThe proposed technique allows for real-time simultaneous motion and shim correction with no additional scanning time, enabling accurate CEST quantification even in the presence of motion and field inhomogeneity.

Indexed as

Magnetic Resonance ImagingMotionAdultAlgorithmsArtifactsHealthy VolunteersHumansImage EnhancementImage Interpretation, Computer-AssistedImage Processing, Computer-AssistedImaging, Three-DimensionalLinear ModelsMaleMuscle, SkeletalPhantoms, ImagingReproducibility of ResultsB0 correctionCESTchemical exchange saturation transferdouble volumetric navigatorDvNavglycogenmotion correction

Identifiers

PMID30506877
PMCPMC7251754
OpenAlexW2903079533

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.