ArticleJournal of veterinary internal medicine2019
Differences in miRNA differential expression in whole blood between horses with sarcoid regression and progression.
Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Profiling of the microRNA transcriptome in feline whole blood.Scientific reports · 2025Article
- Identification and characterisation of temporal abundance of microRNAs in synovial fluid from an experimental equine model of osteoarthritis.Equine veterinary journal · 2025Article
- The potential of three whole blood microRNAs to predict outcome and monitor treatment response in sarcoid-bearing equids.Veterinary research communications · 2023Article
- Diagnostic and prognostic potential of eight whole blood microRNAs for equine sarcoid disease.PloS one · 2021Article
- Diagnostic potential of three serum microRNAs as biomarkers for equine sarcoid disease in horses and donkeys.Journal of veterinary internal medicine · 2021Article
- Mobility and Invasion Related Gene Expression Patterns in Equine Sarcoid.Animals : an open access journal from MDPI · 2020Article
- miRNA-mRNA Integrated Analysis Reveals Roles for miRNAs in a Typical Halophyte,Plants (Basel, Switzerland) · 2020Article
- Differences in miRNA differential expression in whole blood between horses with sarcoid regression and progression.Journal of veterinary internal medicine · 2019Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCurrently no methods are available to predict the clinical outcome of individual horses with equine sarcoid (ES) disease.
objectiveTo investigate if whole blood microRNA (miRNA) profiles can predict the long-term development of ES tumors. ANIMALS: Five horses with regression and 5 with progression of ES lesions monitored over 5-7 years and 5 control horses free of ES for at least 5 years.
methodsFor this cohort study, RNA extracted from whole blood samples from the regression, progression, and control groups was used for high throughput sequencing. Known and novel miRNAs were identified using miRDeep2 and differential expression analysis was carried out by the DESeq2 algorithm. Target gene and pathway prediction as well as enrichment and network analyses were conducted using TarBase, mirPath, and metaCore from GeneGo.
resultsFourteen miRNAs were differentially expressed between regression and progression groups after accounting for the control condition: 4 miRNAs (28.6%) were upregulated and 10 miRNAs (71.4%) were downregulated with >2-fold change. Seven of the 10 downregulated miRNAs are encoded in an miRNA cluster on equine chromosome 24, homologous to the well-known 14q32 cluster in humans. Their target genes show enrichment for pathways involved in viral carcinogenesis. CONCLUSIONS AND CLINICAL IMPORTANCE: Whole blood miRNA expression profiles are associated with long-term ES growth in horses and warrant further validation as prognostic biomarkers in a larger study cohort. Deregulation of miRNAs on equine chromosome 24 might represent a trigger for ES development.
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