ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2019
Functional status at listing predicts waitlist and posttransplant mortality in pediatric liver transplant candidates.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Malnutrition, Frailty, and Sarcopenia in Patients With Cirrhosis: 2021 Practice Guidance by the American Association for the Study of Liver Diseases.Hepatology (Baltimore, Md.) · 2021Guideline
- Longitudinal Assessment of Performance Status in US Liver Transplantation: National Trends and Survival Implications.Transplantation direct · 2025Article
- Effect of frailty as measured by functional impairment on long-term outcomes in liver transplantation in the United States.World journal of transplantation · 2025Article
- Heart Transplant Equity: Effect of 2018 Allocation Policy Change on Recipient Mortality and Morbidity by Race and Ethnicity.Journal of the American College of Surgeons · 2025Article
- Association of Functional, Academic, Motor, and Cognitive Deficits in Graft Failure in Pediatric Liver Transplantation.Clinical transplantation · 2025Article
- Clinical Application of Frailty in the Evaluation of Solid Organ Transplant Patients.Current transplantation reports · 2024Article
- Review
- Association of state Medicaid expansion policies with pediatric liver transplant outcomes.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024Article
- Poor functional status at the time of waitlist for pediatric lung transplant is associated with worse pretransplant outcomes.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023Article
- The Additive Value of Radiomics Features Extracted from Baseline MR Images to the Barcelona Clinic Liver Cancer (BCLC) Staging System in Predicting Transplant-Free Survival in Patients with Hepatocellular Carcinoma: A Single-Center Retrospective Analysis.Diagnostics (Basel, Switzerland) · 2023Article
- Association of Primary Care Shortage Areas with Adverse Outcomes after Pediatric Liver Transplant.The Journal of pediatrics · 2022Observational
- A decline in functional status while awaiting liver transplantation is predictive of increased post-transplantation mortality.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2022Article
- Short-term and mid-term effects of thoracoscopic repair of esophageal atresia: No anastomotic leaks or conversions to open technique.Frontiers in surgery · 2022Article
- Evaluating the Associations Between the Liver Frailty Index and Karnofsky Performance Status With Waitlist Mortality.Transplantation direct · 2021Article
- Association of Karnofsky Performance Status with waitlist mortality among older and younger adults awaiting kidney transplantation.Clinical transplantation · 2020Article
- HEP-Net opinion on the management of ascites and its complications in the setting of decompensated cirrhosis in the resource constrained environment of Pakistan.Pakistan journal of medical sciencesArticle
- Clinical Characteristics Associated With Posttransplant Survival Among Adults 70 Years Old or Older Undergoing Liver Transplantation.Journal of clinical gastroenterologyArticle
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3 authors.
Funding
Abstract
Functional impairment is associated with mortality in adult liver transplant candidates. This has not been studied in pediatric liver transplant candidates. United Network for Organ Sharing Standard Transplant Analysis and Research files were used to investigate functional status, waitlist mortality, and posttransplant outcomes in children younger than 18 years who were waitlisted in 2006-2016 for primary liver transplant. Functional status was categorized, by using the Lansky Play-Performance Scale (LPPS), as normal/good (80-100), moderately impaired (50-70), or severely impaired (10-40) by center assessment. Among 3250 children not listed as Status 1A, 62% had an LPPS score of 80-100, 25% had a score of 50-70, and 13% had a score of 10-40 at listing. Children with an LPPS score of 10-40 at listing were more likely to die while on the waitlist (standardized hazard ratio 1.85, 95% confidence interval 1.09-3.13, P = .02) in analyses adjusting for being on a ventilator, breathing support, or dialysis and other illness severity measures. For the 2565 children transplanted, an LPPS score of 10-40 at listing drastically increased mortality risk by 1 year posttransplant (hazard ratio 5.77, 95% confidence interval 3.05-10.91, P < .0005). LPPS scores of 10-40 and 50-70 both increased the risk of graft loss by 1 year. Functional status is an independent predictor of waitlist and posttransplant mortality in pediatric liver transplant candidates. Validated tools for the assessment of functional status in these children would improve our ability to predict mortality risk-and to appropriately prioritize them for transplant.
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