Evidence map›Paper›PMID 30506579›Full record

Trial reportThe Journal of physiology2019

Amplification of endothelium-dependent vasodilatation in contracting human skeletal muscle: role of K

Christopher M Hearon, Jennifer C Richards, Mathew L Racine, Gary J Luckasen, Dennis G Larson, Frank A Dinenno

Open access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in The Journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Endogenous muscarinic acetylcholine receptor signaling blunts αAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
  3. Integrating molecular and cellular components of endothelial shear stress mechanotransduction.American journal of physiology. Heart and circulatory physiology · 2024
    Review
  4. Visceral adipose of obese mice inhibits endothelial inwardly rectifying KAmerican journal of physiology. Cell physiology · 2024
    Article
  5. Impact of aging on vascular ion channels: perspectives and knowledge gaps across major organ systems.American journal of physiology. Heart and circulatory physiology · 2023
    Review
  6. Article
  7. In utero hypoxia attenuated acetylcholine-mediated vasodilatation via CHRM3/p-NOS3 in fetal sheep MCA: role of ROS/ERK1/2.Hypertension research : official journal of the Japanese Society of Hypertension · 2022
    Article
  8. Review
  9. ATP and acetylcholine interact to modulate vascular tone and αJournal of applied physiology (Bethesda, Md. : 1985) · 2021
    Article
  10. The role of the endothelium in the hyperemic response to passive leg movement: looking beyond nitric oxide.American journal of physiology. Heart and circulatory physiology · 2021
    Article
  11. Methyl-Beta-Cyclodextrin Restores KJournal of Alzheimer's disease reports · 2021
    Article
  12. Impairment of Flow-Sensitive Inwardly Rectifying KArteriosclerosis, thrombosis, and vascular biology · 2020
    Article
  13. Article
  14. KThe Journal of physiology · 2020
    Article
  15. Review
  16. Review
  17. Electrical amplification: KThe Journal of physiology · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Christopher M HearonHuman Cardiovascular Physiology Laboratory, Department of Health and Exercise Science, Colorado State University, Fort Collins, CO, 80523, USA.ORCID 0000-0002-6561-3532
Jennifer C RichardsHuman Cardiovascular Physiology Laboratory, Department of Health and Exercise Science, Colorado State University, Fort Collins, CO, 80523, USA.
Mathew L RacineHuman Cardiovascular Physiology Laboratory, Department of Health and Exercise Science, Colorado State University, Fort Collins, CO, 80523, USA.ORCID 0000-0002-8377-3556
Gary J LuckasenMedical Center of the Rockies Foundation, University of Colorado Health, Loveland, CO, USA.
Dennis G LarsonMedical Center of the Rockies Foundation, University of Colorado Health, Loveland, CO, USA.
Frank A DinennoHuman Cardiovascular Physiology Laboratory, Department of Health and Exercise Science, Colorado State University, Fort Collins, CO, 80523, USA.ORCID 0000-0003-4644-3213
Colorado State University · USColorado Health Foundation · US

Funding

Exercise Hyperemia in HumansR01HL119337 · NHLBI · MAYO CLINIC ROCHESTER · PI DINENNO, FRANK A, JOYNER, MICHAEL J · 2014 to 2017
$3.0M
HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI) R01HL119337NHLBI NIH HHS R01 HL119337NIH HHS R01HL119337
6 · The paper itself

Abstract

key pointsIn humans, the vasodilatory response to skeletal muscle contraction is mediated in part by activation of inwardly rectifying potassium (K ABSTRACT: The local vasodilatory response to muscle contraction is due in part to the activation of inwardly rectifying potassium (K

Indexed as

AcetylcholineAdultBarium CompoundsChloridesEndothelium, VascularExerciseFemaleForearmHand StrengthHumansMaleMuscle ContractionMuscle, SkeletalNitroprussidePotassium Channel BlockersPotassium Channels, Inwardly RectifyingAcetylcholinebarium chlorideBarium CompoundsChloridesNitroprussidePotassium Channel BlockersPotassium Channels, Inwardly RectifyingVasodilator Agentsendothelium-dependent hyperpolarizationexercise hyperaemiaInwardly rectifying potassium channels

Identifiers

PMID30506579
PMCPMC6395423
OpenAlexW2908879887

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.