SynthesisTechniques in coloproctology2018
Systematic review of outcomes following pelvic exenteration for the treatment of primary and recurrent locally advanced rectal cancer.
Synthesis in Techniques in coloproctology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- The role of particle therapy in the treatment of locally recurrent rectal cancer: a systematic review.Radiology and oncology · 2026Pooled it
- Simultaneous robotic-assisted prostatectomy and rectal resection: a systematic review.Journal of robotic surgery · 2025Pooled it
- A systematic review of oncosurgical and quality of life outcomes following pelvic exenteration for locally advanced and recurrent rectal cancer.Annals of the Royal College of Surgeons of England · 2025Pooled it
- Radical resection of locally advanced and recurrent colorectal carcinoma involving major nerve resection: a systematic review of surgical, oncological and functional outcomes.International journal of colorectal disease · 2024Pooled it
- Clinical Implementation and Perioperative Outcomes of Robot-Assisted Pelvic Exenteration for Primary Rectal Cancer: A Multicenter Japanese Experience.Annals of gastroenterological surgery · 2026Article
- Exenterative Surgery in Advanced Pelvic Cancer: Survival Outcomes and an Exploratory Predictive Modeling Framework for Surgical Decision Support.Diagnostics (Basel, Switzerland) · 2026Article
- Real-World Performance of the Veriset Hemostatic Patch: A Multicenter Study of Adjunctive Hemostasis.Medical devices (Auckland, N.Z.) · 2026Article
- Modern Approaches to Rectal Cancer: Integrating Endoscopic, Surgical, and Oncological Care.Cancers · 2025Review
- Entero-vascular fistula following radiotherapy in a patient with recurrent cervical cancer post-pelvic exenteration: a case report.BMC women's health · 2025Article
- Article
- Long-term survival and quality of life in patients more than 10 years after pelvic exenteration.The British journal of surgery · 2025Article
- Management of enteroperineal fistulas following pelvic exenteration: Insights from a high-volume referral centre.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Article
- Propensity-score matched outcomes of minimally invasive and open pelvic exenteration in locally advanced rectal cancer.Updates in surgery · 2025Article
- Patterns of Care and Oncologic Outcomes after Pelvic Exenteration for Locally Advanced Rectal Cancer in the United States.Annals of surgical oncology · 2025Article
- Cost Analysis of Pelvic Exenteration Surgery for Advanced Pelvic Malignancy.Annals of surgical oncology · 2024Article
- Robotic versus open and laparoscopic pelvic exenterations for pelvic cancer: a multicenter propensity-matched analysis in Japan.Surgical endoscopy · 2024Article
- [Interdisciplinary surgical spectrum in cooperation of abdominal surgery and gynecology : What must the (general/abdominal) surgeon know?]Chirurgie (Heidelberg, Germany) · 2024Review
- A novel classification of posterior pelvic exenteration to assess prognosis in female patients with locally advanced primary rectal cancer: a retrospective cohort study from China PelvEx collaborative.International journal of colorectal disease · 2024Article
- The empty pelvis syndrome: a core data set from the PelvEx collaborative.The British journal of surgery · 2024Article
- Retrospective study of combined pelvic exenteration in the treatment of primary and recurrent pelvic malignant tumors.Journal of gastrointestinal oncology · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPelvic exenteration represents the best treatment option for cure of locally advanced or recurrent rectal cancer. This systematic review sought to evaluate current literature regarding short and long term treatment outcomes and long term survival following pelvic exenteration.
methodsA systematic search of the MEDLINE, PubMed and Ovid databases was conducted to identify suitable articles published between 2001 and 2016. The article search was performed in line with Cochrane methodology and reported according to the Preferred Reporting Items for Systematic reviews and Meta-analyses statement.
resultsSixteen studies were included in the final analysis, incorporating 1016 patients. Sixty-three percent of patients were male and median patient age was 59 years. Median operating time was 7.2 h with median blood loss of 1.9 l. Median postoperative stay was 17 days with a median 30-day mortality of 0. Complication rates were 31.6-86% with a return to theatre rate of 14.6%. Median R0 resection rate was 74% and was higher for primary cancer (82.6% versus 58% for recurrent cancer). Mean overall survival was 31 months and median 5-year survival was 32%. Recurrently identified indicators of adverse outcome included R1/2 resection, preoperative pelvic pain and previous abdominoperineal resection of the rectum.
conclusionsPelvic exenteration remains a major operation associated with significant morbidity and mortality. Despite advances in preoperative assessment and staging, R1 resection rates remain high. There is also a high degree of variability of reporting outcomes and standardisation of this process would aid comparison of results between centres and drive forward research in this area.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.