Evidence map›Paper›PMID 30506486›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2019

Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections.

Manu N Capoor, Jan Lochman, Andrew McDowell, Jonathan E Schmitz, Martin Solansky, Martina Zapletalova, Todd F Alamin, Michael F Coscia, Steven R Garfin, Radim Jancalek and 6 more

Erratum issuedAbstract read
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In one paragraph

Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Human intervertebral discs harbour a unique microbiome and dysbiosis determines health and disease.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Manu N CapoorLaboratory of Bacterial Pathogenesis and Immunology, Rockefeller University, 1230 York Avenue, New York, NY, USA. mcapoor@mail.rockefeller.edu.ORCID 0000-0002-0861-4993
Jan LochmanDepartment of Biochemistry, Faculty of Science, Masaryk University, Brno, Czech Republic.
Andrew McDowellNorthern Ireland Centre for Stratified Medicine, School of Biomedical Sciences, Ulster University, Londonderry, UK.
Jonathan E SchmitzDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Martin SolanskyDepartment of Biochemistry, Faculty of Science, Masaryk University, Brno, Czech Republic.
Martina ZapletalovaDepartment of Biochemistry, Faculty of Science, Masaryk University, Brno, Czech Republic.
Todd F AlaminDepartment of Orthopedic Surgery, Stanford University Medical Center, Stanford University, Stanford, CA, USA.
Michael F CosciaDepartment of Orthopedic Surgery, OrthoIndy Hospital, Indianapolis, IN, USA.
Steven R GarfinDepartment of Orthopaedic Surgery, University of California San Diego, San Diego, CA, USA.
Radim JancalekDepartment of Neurosurgery, Masaryk University, St. Anne's University Hospital, Brno, Czech Republic.
Filip RuzickaDepartment of Microbiology, Masaryk University, St. Anne's University Hospital, Brno, Czech Republic.
A Nick ShamieDepartment of Orthopaedic Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Martin SmrckaDepartment of Neurosurgery, University Hospital Brno, Masaryk University, Brno, Czech Republic.
Jeffrey C WangDepartment of Orthopedic Surgery, University Southern California, Los Angeles, CA, USA.
Christof BirkenmaierDepartment of Orthopedics, Physical Medicine and Rehabilitation, University of Munich (LMU), Munich, Germany.
Ondrej SlabyCentral European Institute of Technology (CEITEC), Masaryk University, Kamenice 753/5, 625 00, Brno, Czech Republic. ondrej.slaby@ceitec.muni.cz.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe presence of Propionibacterium acnes in a substantial component of resected disc specimens obtained from patients undergoing discectomy or microdiscectomy has led to the suggestion that this prominent human skin and oral commensal may exacerbate the pathology of degenerative disc disease. This hypothesis, therefore, raises the exciting possibility that antibiotics could play an important role in treating this debilitating condition. To date, however, little information about antibiotic penetration into the intervertebral disc is available.

methodsIntervertebral disc tissue obtained from 54 microdiscectomy patients given prophylactic cefazolin (n = 25), clindamycin (n = 17) or vancomycin (n = 12) was assayed by high-performance liquid chromatography, with cefaclor as an internal standard, to determine the concentration of antibiotic penetrating into the disc tissue.

resultsIntervertebral disc tissues from patients receiving the positively charged antibiotic clindamycin contained a significantly greater percentage of the antibacterial dose than the tissue from patients receiving negatively charged cefazolin (P < 0.0001) and vancomycin, which has a slight positive charge (P < 0.0001).

conclusionPositively charged antibiotics appear more appropriate for future studies investigating potential options for the treatment of low-virulence disc infections. These slides can be retrieved under Electronic Supplementary Material.

Indexed as

Propionibacterium acnesAdultAnti-Bacterial AgentsCefazolinClindamycinGram-Positive Bacterial InfectionsHumansIntervertebral DiscIntervertebral Disc DegenerationIntervertebral Disc DisplacementVancomycinAnti-Bacterial AgentsCefazolinClindamycinVancomycinBiofilmCefazolinClindamycinCutibacterium acnesDegenerative disc diseasePropionibacterium acnesSurgical prophylaxisVancomycin

Identifiers

PMID30506486

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.