Evidence map›Paper›PMID 30506370›Full record

ArticleJournal of materials science. Materials in medicine2018

Salmon fibrinogen and chitosan scaffold for tissue engineering: in vitro and in vivo evaluation.

Ivo Laidmäe, Kaspars Ērglis, Andrejs Cēbers, Paul A Janmey, Raivo Uibo

Open access · hybridAbstract read
In one paragraph

Article in Journal of materials science. Materials in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Multiple Cell Cultures for MRI Analysis.International journal of molecular sciences · 2022
    Review
  3. Article
  4. Article
  5. Review
  6. Natural polymer-based scaffolds for soft tissue repair.Frontiers in bioengineering and biotechnology · 2022
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Ivo LaidmäeDepartment of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411, Tartu, Estonia. ivo.laidmae@ut.ee.ORCID http://orcid.org/0000-0001-5559-5476
Kaspars ĒrglisFaculty of Physics, Mathematics and Optometry, University of Latvia, Riga, LV-1002, Latvia.
Andrejs CēbersFaculty of Physics, Mathematics and Optometry, University of Latvia, Riga, LV-1002, Latvia.
Paul A JanmeyInstitute for Medicine and Engineering and Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Raivo UiboDepartment of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411, Tartu, Estonia.
University of Latvia · LVUniversity of Tartu · EEUniversity of Pennsylvania · US

Funding

Eesti Teadusagentuur IUT20-43Eesti Teadusagentuur IUT34-18
6 · The paper itself

Abstract

3D fibrous scaffolds have received much recent attention in regenerative medicine. Use of fibrous scaffolds has shown promising results in tissue engineering and wound healing. Here we report the development and properties of a novel fibrous scaffold that is useful for promoting wound healing. A scaffold made of salmon fibrinogen and chitosan is produced by electrospinning, resulting in a biocompatible material mimicking the structure of the native extracellular matrix (ECM) with suitable biochemical and mechanical properties. The scaffold is produced without the need for enzymes, in particular thrombin, but is fully compatible with their addition if needed. Human dermal fibroblasts cultured on this scaffold showed progressive proliferation for 14 days. Split-thickness experimental skin wounds treated and untreated were compared in a 10-day follow-up period. Wound healing was more effective using the fibrinogen-chitosan scaffold than in untreated wounds. This scaffold could be applicable in various medical purposes including surgery, tissue regeneration, burns, traumatic injuries, and 3D cell culture platforms.

Indexed as

SalmonAnimalsBiocompatible MaterialsCell ProliferationChitosanElectrochemical TechniquesFibrinogenFibroblastsHumansRatsSurface PropertiesTissue EngineeringTissue ScaffoldsWound HealingBiocompatible MaterialsChitosanFibrinogen

Identifiers

PMID30506370
PMCPMC6267118
OpenAlexW2903165427

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.