Evidence map›Paper›PMID 30506224›Full record

ArticleEuropean radiology2019

Evaluation of a free-breathing respiratory-triggered (Navigator) 3-D T1-weighted (T1W) gradient recalled echo sequence (LAVA) for detection of enhancement in cystic and solid renal masses.

Wendy Tu, Abdulrahman Alzahrani, Stephen Currin, Cindy Walsh, Sabarish Narayanasamy, Matthew D F McInnes, Nicola Schieda

Abstract read
PubMed Publisher
In one paragraph

Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Update on MRI of Cystic Renal Masses Including Bosniak Version 2019.Journal of magnetic resonance imaging : JMRI · 2021
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Wendy TuThe Ottawa Hospital, The University of Ottawa, 1053 Carling Avenue, Ottawa, Ontario, K1Y 4E9, Canada.
Abdulrahman AlzahraniThe Ottawa Hospital, The University of Ottawa, 1053 Carling Avenue, Ottawa, Ontario, K1Y 4E9, Canada.
Stephen CurrinThe Ottawa Hospital, The University of Ottawa, 1053 Carling Avenue, Ottawa, Ontario, K1Y 4E9, Canada.
Cindy WalshThe Ottawa Hospital, The University of Ottawa, 1053 Carling Avenue, Ottawa, Ontario, K1Y 4E9, Canada.
Sabarish NarayanasamyThe Ottawa Hospital, The University of Ottawa, 1053 Carling Avenue, Ottawa, Ontario, K1Y 4E9, Canada.
Matthew D F McInnesThe Ottawa Hospital, The University of Ottawa, 1053 Carling Avenue, Ottawa, Ontario, K1Y 4E9, Canada.
Nicola SchiedaThe Ottawa Hospital, The University of Ottawa, 1053 Carling Avenue, Ottawa, Ontario, K1Y 4E9, Canada. nschieda@toh.on.ca.
Ottawa Hospital · CAUniversity of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate free-breathing Navigator-triggered 3-D T1-weighted MRI (NAV-LAVA) compared to breath-hold (BH)-LAVA among cystic and solid renal masses. MATERIALS AND

methodsWith an IRB waiver, 44 patients with 105 renal masses (71 non-enhancing cysts and 14 cystic and 20 solid renal masses) underwent MRI between 2016 and 2017 where BH-LAVA and NAV-LAVA were performed. Subtraction images were generated for BH-LAVA and NAV-LAVA using pre- and 3-min post-gadolinium-enhanced images and were evaluated by two blinded radiologists for overall image quality, image sharpness, motion artifact, and quality of subtraction (using 5-point Likert scales) and presence/absence of enhancement. Percentage signal intensity change (Δ%SI) = ([SI.post-gadolinium-SI.pre-gadolinium]/SI.pre-gadolinium)*100, was measured on BH-LAVA and NAV-LAVA. Likert scores were compared using Wilcoxon's sign-rank test and accuracy for detection of enhancement compared using receiver operator characteristic (ROC) analysis.

resultsOverall image quality (p = 0.002-0.141), image sharpness (p = 0.002-0.031), and motion artifact were better (p = 0.002) comparing BH-LAVA to NAV-LAVA for both radiologists; however, quality of image subtraction did not differ between groups (p = 0.09-0.14). Sensitivity/specificity/area under ROC curve for enhancement in cystic and solid renal masses using subtraction and %SIΔ were (1) BH-LAVA: 64.7%/98.6%/0.82 (radiologist 1), 61.8%/95.8%/0.79 (radiologist 2), and 70.6%/81.7%/0.76 (%SIΔ) versus 2) NAV-LAVA: 58.8%/95.8%/0.79 (radiologist 1, p = 0.16), 58.8%/88.7%/0.73 (radiologist 2, p = 0.37), and 73.5%/76.1%/0.75 (%SIΔ, p = 0.74).

conclusionsNAV-LAVA showed similar quality of subtraction and ability to detect enhancement compared to BH-LAVA in renal masses albeit with lower image quality, image sharpness, and increased motion artifact. NAV-LAVA may be considered in renal MRI for patients where BH is suboptimal. KEY POINTS: • Free-breathing Navigator (NAV) 3-D subtraction MRI is comparable to breath-hold (BH) images. • Accuracy for subjective and quantitative diagnosis of enhancement in renal masses on NAV 3-D T1W is comparable to BH MRI. • NAV 3-D T1W renal MRI is useful in patients who may not be able to adequately BH.

Indexed as

ArtifactsFemaleGadolinium DTPAHumansImage EnhancementKidney Diseases, CysticKidney NeoplasmsMagnetic Resonance ImagingMaleMiddle AgedRespirationROC CurveGadolinium DTPAImage enhancementKidneyMagnetic resonance imagingNeoplasmsRenal cell carcinoma

Identifiers

PMID30506224
OpenAlexW2902918127

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.