Evidence map›Paper›PMID 30506120›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2019

Relationship between thiol-disulphide homeostasis and visual evoked potentials in patients with multiple sclerosis.

Gönül Vural, Şadiye Gümüşyayla, Orhan Deniz, Salim Neşelioğlu, Özcan Erel

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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Oxidative Stress in Optic Neuropathies.Antioxidants (Basel, Switzerland) · 2021
    Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gönül VuralDepartment of Neurology, Faculty of Medicine, Yıldırım Beyazıt University, 06800, Ankara, Turkey. gonulvrl@gmail.com.ORCID http://orcid.org/0000-0002-1245-7273
Şadiye GümüşyaylaDepartment of Neurology, Faculty of Medicine, Yıldırım Beyazıt University, 06800, Ankara, Turkey.
Orhan DenizDepartment of Neurology, Faculty of Medicine, Yıldırım Beyazıt University, 06800, Ankara, Turkey.
Salim NeşelioğluDepartment of Clinical Biochemistry, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey.
Özcan ErelDepartment of Clinical Biochemistry, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo examine the thiol-disulphide homeostasis during an optic neuritis episode in patients with multiple sclerosis and the relationship between this homeostasis and P100 wave latency. MATERIALS AND

methodVisual evoked potential reviews of multiple sclerosis patients who presented with an optic neuritis episode were conducted and P100 latencies were measured. Peripheral blood samples were collected from all patients. Native thiol and total thiol concentrations were measured with the automated method that was recently developed. Their amount of disulphide bonds, disulphide/native thiol, disulphide/total thiol and native thiol/total thiol ratios were calculated. The relationship between P100 latency and thiol-disulphide homeostasis was investigated.

resultsA significant positive correlation was determined between the disulphide/native thiol ratio and both mean P100 latency and maximum P100 latency (p = 0.021, r = 0.136; p = 0.030, r = 0.177, respectively). DISCUSSION: As the balance of the plasma dominated by antioxidants moves towards the oxidant side, in other words as a higher rate of thiol is oxidised from the thiol pool, P100 latency is extended. N-acetylcysteine and alpha lipoic acid as well as thiol supplements can improve the thiol-disulphide balance, reinforce antioxidant defence and it can help in slowing down the demyelinating damage.

Indexed as

Evoked Potentials, VisualAdolescentAdultDisulfidesFemaleHomeostasisHumansMaleMiddle AgedMultiple Sclerosis, Relapsing-RemittingOptic NeuritisOxidative StressSulfhydryl CompoundsYoung AdultDisulfidesSulfhydryl CompoundsMultiple sclerosisOptic neuritisOxidative stressThiol-disulphide homeostasisVisual evoked potential

Identifiers

PMID30506120

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.