ArticleQuantitative imaging in medicine and surgery2018
Radiation-induced gray matter atrophy in patients with nasopharyngeal carcinoma after intensity modulated radiotherapy: a MRI magnetic resonance imaging voxel-based morphometry study.
Article in Quantitative imaging in medicine and surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Radiomitigators: Breakthroughs in Post-Radiation Recovery.Antioxidants (Basel, Switzerland) · 2026Review
- Hippocampal Atrophy Following Therapeutic Irradiation of Intracranial and Nasopharyngeal Tumors.Cureus · 2025Review
- Evaluation of hippocampus-sparing VMAT versus conventional VMAT in locally advanced nasopharyngeal carcinoma: a dosimetric and biological analysis.Frontiers in oncology · 2025Article
- Radiation-induced aberrant structural covariance networks in patients with nasopharyngeal carcinoma: a source-based morphometry study.Quantitative imaging in medicine and surgery · 2024Article
- Longitudinal brain volumetrics in glioma survivors.Journal of neurosurgery · 2024Article
- Unilateral hippocampal sparing during whole brain radiotherapy for multiple brain metastases: narrative and critical review.Frontiers in oncology · 2024Review
- Specific-CT brain template construction and retrospective dosimetric comparison study in brain for nasopharyngeal carcinoma patients treated with IMRT or VMAT.American journal of cancer research · 2024Article
- Effects of proton therapy on regional [Clinical and translational radiation oncology · 2023Article
- Measuring out-of-field dose to the hippocampus in common radiotherapy indications.Radiation oncology (London, England) · 2023Article
- A detailed dosimetric comparative study of IMRT and VMAT in normal brain tissues for nasopharyngeal carcinoma patients treated with radiotherapy.Frontiers in radiology · 2023Article
- Voxel based morphometry-detected white matter volume loss after multi-modality treatment in high grade glioma patients.PloS one · 2023Article
- Neuroanatomical changes seen in MRI in patients with cerebral metastasized breast cancer after radiotherapy.Tumori · 2022Article
- Overestimation of grey matter atrophy in glioblastoma patients following radio(chemo)therapy.Magma (New York, N.Y.) · 2022Article
- Quality assurance for MRI-only radiation therapy: A voxel-wise population-based methodology for image and dose assessment of synthetic CT generation methods.Frontiers in oncology · 2022Article
- Interaction of chemotherapy and radiotherapy in altering the shape of subcortical structures in patients with nasopharyngeal carcinoma.Frontiers in oncology · 2022Article
- Divergent effects of irradiation on brain cortical morphology in patients with nasopharyngeal carcinoma: one-year follow-up study using structural magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2021Article
- Early postnatal irradiation-induced age-dependent changes in adult mouse brain: MRI based characterization.BMC neuroscience · 2021Article
- Review
- Functional Connectivity Density for Radiation Encephalopathy Prediction in Nasopharyngeal Carcinoma.Frontiers in oncology · 2021Article
- Neuroanatomical substrates underlying contrast sensitivity.Quantitative imaging in medicine and surgery · 2019Article
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10 authors.
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Abstract
backgroundGray matter (GM) damage after radiotherapy (RT) in nasopharyngeal carcinoma (NPC) patients can result in cognitive impairment, while there may be no visible brain tissue change according to the conventional magnetic resonance imaging (MRI). This study investigated radiation-induced GM volume differences between NPC patients who received RT and those who did not.
methodsHigh-resolution brain structural MRI data from two groups of patients were acquired. The pre-RT group was composed of 56 newly diagnosed but not yet medically treated NPC patients, while the after-RT group consisted of 40 NPC patients who had completed RT more than 1 year ago. Voxel-based morphometry (VBM) was applied to assess GM volumes. Two sample t-test was used to analyze GM volumes voxel-by-voxel using the VBM8 toolbox built in the SPM software. Radiation-induced cortical volume alteration in all NPC patients after RT and dosimetry of 36 patients were analyzed.
resultsCompared to pre-treatment group, cortical volumes of GM were significantly smaller in the left hippocampus, the right pulvinar and the right middle temporal gyrus (MTG, P<0.001, AlphaSim correction, cluster size ≥157). The mean dose (D
conclusionsRadiation to the NPC patients can not only induce damage of the hippocampus, but also other secondary damages of GM.
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