Evidence map›Paper›PMID 30505666›Full record

ArticleActa pharmaceutica Sinica. B2018

The enzymatic biosynthesis of acylated steroidal glycosides and their cytotoxic activity.

Ming Liu, Jian-Qiang Kong

Open access · diamondAbstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 25 citations in OpenAlex.

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  8. Combinatorial mutation on theActa pharmaceutica Sinica. B · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ming LiuState Key Laboratory of Bioactive Substance and Function of Natural Medicines & Ministry of Health Key Laboratory of Biosynthesis of Natural Products, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Jian-Qiang KongState Key Laboratory of Bioactive Substance and Function of Natural Medicines & Ministry of Health Key Laboratory of Biosynthesis of Natural Products, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein we describe the discovery and functional characterization of a steroidal glycosyltransferase (SGT) from

Indexed as

6′-AE-17β-G, 6′-acetylated estradiol 17-O-β-glucoside6′-AT-17β-G, 6′-acetylated testosterone 17-O-β-glucosideAcylated steroidal glyco sidesAE-17β-G, acetylated estradiol-17-O-β-glucosideASGs, acylated steroidal glycosidesAT-17β-G, acetylated testosterone-17-O-β-glucosideE-17β-G, estradiol-17-O-β-glucosideEcSGA1, E. coli steroidal glucoside acetyltransferaseHPLC—SPE—NMR, high-performance liquid chromatography–solid phase extraction–NMR spectroscopyIPTG, isopropyl-β-D-thiogalactosideLacAORF, open reading frameOrnithogalum saunder siaePSBD, putative steroid-binding domainPSPG, plant secondary product glycosyltranferase boxRIN, RNA integrity numberRP-HPLC, reversed phase high-performance liquid chromatographySDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresisSGAs, steroidal glycoside acyltransferasesSGEs, steroidal glycoside estersSGs, steroidal glycosidesSGTs, steroidal glycosyltransferasesSteroidal glycoside acyl transferaseSteroidal glycosyltrans feraseT-17β-G, testosterone-17-O-β-glucosideUDP-Ara, UDP-l-arabinoseUDP-GalA, UDP-D-Galacturonic acidUDP-Gal, UDP-D-galactoseUDP-GlcA, UDP-D-glucuronic acidUDP-GlcNAc, UDP-N-acetylglucosamineUDP-Glc, UDP-D-glucoseUDP-Xyl, UDP-D-xyloseUTR, untranslated region

Identifiers

PMID30505666
PMCPMC6251810
OpenAlexW2800866502

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.