Evidence map›Paper›PMID 30505627›Full record

ArticleNature biomedical engineering2018

An intravascular magnetic wire for the high-throughput retrieval of circulating tumour cells in vivo.

Ophir Vermesh, Amin Aalipour, T Jessie Ge, Yamil Saenz, Yue Guo, Israt S Alam, Seung-Min Park, Charlie N Adelson, Yoshiaki Mitsutake, Jose Vilches-Moure and 10 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature biomedical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 116 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Swarm Autonomy: From Agent Functionalization to Machine Intelligence.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Recent Advancements in Technologies to Detect EnterohaemorrhagicJournal of microbiology and biotechnology · 2023
    Review
  16. Article
  17. Rotary Structural Color Spindles from Droplet Confined Magnetic Self-Assembly.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 1 country.

Ophir VermeshMolecular Imaging Program at Stanford, Stanford University, Stanford, CA, USA.
Amin AalipourMolecular Imaging Program at Stanford, Stanford University, Stanford, CA, USA.
T Jessie GeMolecular Imaging Program at Stanford, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-3618-3051
Yamil SaenzDepartment of Radiology, Stanford University School of Medicine, Stanford, CA, USA.
Yue GuoDepartment of Electrical Engineering, Stanford University, Stanford, CA, USA.
Israt S AlamMolecular Imaging Program at Stanford, Stanford University, Stanford, CA, USA.
Seung-Min ParkMolecular Imaging Program at Stanford, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-2123-6245
Charlie N AdelsonDepartment of Chemistry, Stanford University, Stanford, CA, USA.
Yoshiaki MitsutakeDivision of Cardiovascular Medicine, Stanford University, Stanford, CA, USA.
Jose Vilches-MoureDepartment of Comparative Medicine, Stanford University, Stanford, CA, USA.
Elias GodoyDepartment of Comparative Medicine, Stanford University, Stanford, CA, USA.
Michael H BachmannDepartment of Radiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-0204-3720
Chin Chun OoiDepartment of Chemical Engineering, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-4813-4529
Jennifer K LyonsDepartment of Chemistry, Stanford University, Stanford, CA, USA.
Kerstin MuellerDepartment of Radiology, Stanford University School of Medicine, Stanford, CA, USA.
Hamed AramiMolecular Imaging Program at Stanford, Stanford University, Stanford, CA, USA.
Alfredo GreenDivision of Cardiovascular Medicine, Stanford University, Stanford, CA, USA.
Edward I SolomonDepartment of Chemistry, Stanford University, Stanford, CA, USA.
Shan X WangDepartment of Electrical Engineering, Stanford University, Stanford, CA, USA.
Sanjiv S GambhirMolecular Imaging Program at Stanford, Stanford University, Stanford, CA, USA. sgambhir@stanford.edu.ORCID http://orcid.org/0000-0002-2711-7554
Stanford University · USHoward Hughes Medical Institute · USStanford Medicine · US

Funding

Pilot ProjectsU54CA151459 · NCI · STANFORD UNIVERSITY · PI GAMBHIR, SANJIV S · 2010 to 2014
$12.6M
STANFORD CANCER IMAGING TRAINING (SCIT) PROGRAMT32CA009695 · NCI · STANFORD UNIVERSITY · PI BRUCE L DANIEL, Jeremy Dahl · 1993 to 2026
$7.7M
Axiom zeego shared instrument grantS10RR026714 · NCRR · STANFORD UNIVERSITY · PI FAHRIG, REBECCA · 2010 to 2010
$500k
Analysis of CTCs for Early Prediction of Response to Treatment in RCCR21CA185804 · NCI · STANFORD UNIVERSITY · PI FAN, ALICE CHEN, WANG, SHAN X. · 2015 to 2016
$383k
NCI NIH HHS R21 CA185804NCI NIH HHS T32 CA009695NCI NIH HHS U54 CA151459NCRR NIH HHS S10 RR026714
6 · The paper itself

Abstract

The detection and analysis of rare blood biomarkers is necessary for early diagnosis of cancer and to facilitate the development of tailored therapies. However, current methods for the isolation of circulating tumour cells (CTCs) or nucleic acids present in a standard clinical sample of only 5-10 ml of blood provide inadequate yields for early cancer detection and comprehensive molecular profiling. Here, we report the development of a flexible magnetic wire that can retrieve rare biomarkers from the subject's blood in vivo at a much higher yield. The wire is inserted and removed through a standard intravenous catheter and captures biomarkers that have been previously labelled with injected magnetic particles. In a proof-of-concept experiment in a live porcine model, we demonstrate the in vivo labelling and single-pass capture of viable model CTCs in less than 10 s. The wire achieves capture efficiencies that correspond to enrichments of 10-80 times the amount of CTCs in a 5-ml blood draw, and 500-5,000 times the enrichments achieved using the commercially available Gilupi CellCollector.

Identifiers

PMID30505627
PMCPMC6261517
OpenAlexW2883544820

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.