ArticleNature biomedical engineering2017
Glial responses to implanted electrodes in the brain.
Article in Nature biomedical engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 299 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
299 citing papers in PubMed.
- Glutamate signaling and transport around nodes of Ranvier and internodal myelin regions.Histology and histopathology · 2026Review
- Realignment of representational drift in mouse visual cortex via flexible electrode arrays.Nature biomedical engineering · 2026Article
- Zwitterionic Polymer Coating Enabled Chronic Dopamine Sensing and Electrophysiology Recording in Free-Moving Mice.Advanced healthcare materials · 2026Article
- Integrating neural decoding, memristive materials, and adaptive control frameworks for next-generation hippocampal memory prosthetics.iScience · 2026Review
- Closed-Loop Neuroprosthetics: Advancing Long-Term Solutions for Brain-Level Function Restoration.Cureus · 2026Review
- Advancing Type 1 Diabetes Treatment: 3 PM-Oriented Innovations in Islet Transplantation and Biomaterial Engineering.Diabetes/metabolism research and reviews · 2026Review
- Does stereoelectroencephalographic depth electrode insertion alter seizure frequency? A baseline versus endpoint analysis.Epilepsia · 2026Article
- Umbrella-type stretchable electrode arrays for long-term neural recording.Nature communications · 2026Article
- Flexible Multimodal Neural Probe with Integrated Three-Electrode Aptameric Sensing for In Vivo Monitoring of Dopamine Dynamics and Neural Activity.ACS chemical neuroscience · 2026Article
- High-channel-count neural recording and stimulation platform with 5376 simultaneous recording channels.npj biomedical innovations · 2026Article
- Injectable Antifouling Adhesive Hydrogel Enables Robust Neural Interfaces for Stable ECoG Recording.Advanced healthcare materials · 2026Article
- MicroFace maps microglial morphology remodeling, revealing spatial zones and bifurcated trajectories during brain microinjury recovery.iScience · 2026Article
- Seamless human electronics interfacing through advanced skin attachable and implantable sensor technologies.Discover nano · 2026Review
- Implantable pelvic neurostimulators to restore erectile function: from concept to practice.Nature reviews. Urology · 2026Review
- Article
- Electromechanical Properties and Structural Regulation of PEDOT-Derived Gels.Gels (Basel, Switzerland) · 2026Review
- PolyGraph - Flexible, Biocompatible & Electrically Optimized Graphene-Polymer Composites for Next-Generation Neural Interfaces.Advanced healthcare materials · 2026Article
- X-optogenetic inhibition of VTA GABA neurons for wireless deep-brain stimulation and suppression of scratching behavior in freely moving mice.Materials today. Bio · 2026Article
- A comparative study assessing neural recording quality and inflammatory tissue response between stiff and flexible microelectrode arrays.Biomaterials · 2026Article
- Temporally Delayed Deployment of Photo-Responsive Liquid Crystal Polymer Networks Toward Neural Interfaces.Advanced healthcare materials · 2026Article
239 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
The use of implants that can electrically stimulate or record electrophysiological or neurochemical activity in nervous tissue is rapidly expanding. Despite remarkable results in clinical studies and increasing market approvals, the mechanisms underlying the therapeutic effects of neuroprosthetic and neuromodulation devices, as well as their side effects and reasons for their failure, remain poorly understood. A major assumption has been that the signal-generating neurons are the only important target cells of neural-interface technologies. However, recent evidence indicates that the supporting glial cells remodel the structure and function of neuronal networks and are an effector of stimulation-based therapy. Here, we reframe the traditional view of glia as a passive barrier, and discuss their role as an active determinant of the outcomes of device implantation. We also discuss the implications that this has on the development of bioelectronic medical devices.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.