ArticleTurkish journal of anaesthesiology and reanimation2018
Protective Role of Dexmedetomidine on Ileum and Kidney Damage Caused by Mesenchymal Ischaemia in Rats.
Article in Turkish journal of anaesthesiology and reanimation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 8 citations in OpenAlex.
- Determination of SCUBE-1, SCUBE-2, caveolin-1, and ischemia biomarker levels in rats following renal ischemia-reperfusion.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
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3 authors at 3 institutions in 1 country.
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Abstract
objectiveThe aim of this study was to demonstrate ischaemia reperfusion (IR) injury on the ileum and kidney tissue in rats and to evaluate the effect of dexmedetomidine administered at different doses and dosing schedules on recovery.
methodsA total of 30 rats were randomly divided into five groups. Group I: sham; Group II: control; Group III: dexmedetomidine before ischaemia; Group IV: dexmedetomidine after ischaemia; and Group V: dexmedetomidine before and after ischaemia. The malondialdehyde (MDA) and signal peptide-CUB-EGF (epidermal growth factor) domain-containing protein 1 (SCUBE-1) levels of all subjects were studied from the serum, ileum, and kidney tissues. Moreover, the histopathology of ileum and kidney tissues was examined.
resultsThe SCUBE-1 levels were found to be highly similar to the MDA levels in ischaemic groups. The serum SCUBE-1 levels obtained were significantly lower in Group V compared to Groups II, III and IV (p<0.001, p=0.003, p=0.013, respectively). The apoptosis indexes were found to be lower in groups receiving dexmedetomidine compared to Group II. The groups receiving dexmedetomidine were detected to have normal morphological appearance when compared to Group II.
conclusionIn this study, the use of dexmedetomidine in the preoperative and peroperative periods may be beneficial in reducing the negative effects of IR injury.
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