ArticleTurkish journal of anaesthesiology and reanimation2018
The Effects of Lidocaine with Epinephrine on Bupivacaine-Induced Cardiotoxicity.
Article in Turkish journal of anaesthesiology and reanimation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 5 citations in OpenAlex.
- Article
- Efficacy of phentolamine mesylate in reducing the duration of various local anesthetics.Journal of dental anesthesia and pain medicine · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveBupivacaine, a local anaesthetic substance, is used as a regional-anaesthesia agent. Lidocaine, a sodium channel blocker, is used in combination with epinephrine for regional anaesthesia. We aimed to evaluate the effects of lidocaine with epinephrine (LE) at different doses on bupivacaine-induced cardiotoxicity in rats.
methodsIn our study, 24 Wistar albino rats were divided into four groups: I) Control; II) LE, 1 mg kg
resultsLE significantly increased the asystole time and 75% decrement time in MABP at the doses of 3 and 6 mg kg
conclusionThese results reveal that LE has a protective effect against bupivacaine cardiotoxicity. In clinical application, the simultaneous application of LE and bupivacaine may reduce the risk of cardiotoxicity due to bupivacaine.
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