Evidence map›Paper›PMID 30505456›Full record

ArticleMultiple sclerosis journal - experimental, translational and clinical

Can a stress management programme reduce stress and improve quality of life in people diagnosed with multiple sclerosis?

Susan Agland, Amanda Lydon, Sally Shaw, Rodney Lea, Sheila Mortimer-Jones, Jeannette Lechner-Scott

Open access · goldAbstract read
In one paragraph

Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 0 citations in OpenAlex.

  1. Effects of binaural beats on acute stress recovery and autonomic regulation in multiple sclerosis: a pilot double-blind randomized controlled trial.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Susan AglandDepartment of Neurology, John Hunter Hospital, Australia.ORCID https://orcid.org/0000-0003-3897-7274
Amanda LydonDepartment of Neurology, John Hunter Hospital, Australia.
Sally ShawDepartment of Neurology, Eastern Health, Australia.
Rodney LeaDepartment of Neurology, John Hunter Hospital, Australia.
Sheila Mortimer-JonesSchool of Health Professions, Murdoch University, Australia.
Jeannette Lechner-ScottDepartment of Neurology, John Hunter Hospital, Australia.
John Hunter Hospital · AUEastern Health · AUMurdoch University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite evidence of perceived stress as a risk factor for multiple sclerosis activity, the evidence for managing stress is limited.Objective To evaluate a stress management programme on perceived stress and quality of life, over 6 months.

methodsOne hundred people with multiple sclerosis were randomly assigned to either a stress management programme of mindfulness, meditation and progressive muscle relaxation, or wait list. Perceived stress and quality of life were assessed at three intervals across 6 months. Salivary cortisol levels were assessed at two intervals: baseline and first follow-up.

resultsThe stress management programme did not significantly reduce perceived stress, when comparing mean scores. Secondary analysis using median scores found a significant improvement for quality of life, favouring the intervention group.

conclusionStress management had no significant effect on the primary outcome of perceived stress but did improve quality of life in a secondary analysis of median scores.

Indexed as

meditationmindfulnessMultiple sclerosisperceived stressprogressive muscle relaxationstress management

Identifiers

PMID30505456
PMCPMC6256308
OpenAlexW2787560050

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.