ReviewJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2018
Effect of diabetes mellitus type 2 on salivary glucose, immunoglobulin A, total protein, and amylase levels in adults: A systematic review and meta-analysis of case-control studies.
Review in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Major electrolyte disorder and associated factors among patients with chronic disease in Ethiopia: a systematic review and meta-analysis.BMC nephrology · 2024Pooled it
- Effects of salivary amylase gene copy number on metabolic health.Frontiers in nutrition · 2026Review
- Exploring the impact of advanced glycation end products on diabetic salivary gland dysfunctions.Glycoconjugate journal · 2025Review
- Salivary ATR-FTIR Spectroscopy Coupled with Support Vector Machine Classification for Screening of Type 2 Diabetes Mellitus.Diagnostics (Basel, Switzerland) · 2023Article
- Novel impacts of saliva with regard to oral health.The Journal of prosthetic dentistry · 2022Review
- INitial Steps of Insulin Action in Parotid Glands of Male Wistar Rats.Cell biochemistry and biophysics · 2022Article
- Fructose and methylglyoxal-induced glycation alters structural and functional properties of salivary proteins, albumin and lysozyme.PloS one · 2022Article
- Changes in Salivary Amylase and Glucose in Diabetes: A Scoping Review.Diagnostics (Basel, Switzerland) · 2021Article
- Impact of the Glycemic Level on the Salivary Proteome of Middle-Aged and Elderly People With Type 2 Diabetes Mellitus: An Observational Study.Frontiers in molecular biosciences · 2021Article
- The relationship between hemoglobin A1c levels and thrombus load in patients with type 2 diabetes mellitus and non-ST-segment elevation myocardial infarction.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Article
- Non-Invasive Blood Glucose Monitoring Technology: A Review.Sensors (Basel, Switzerland) · 2020Review
- Disruption of tight junctions contributes to hyposalivation of salivary glands in a mouse model of type 2 diabetes.Journal of anatomy · 2020Article
- From Iceberg of Pre-diabetes to Poor Glycemic Control in Diabetics: An Elderly Based Study in Shiraz, South of Iran.International journal of preventive medicine · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSaliva is a fluid with the complex compound which can be used as diagnostic markers for type 2 diabetes (T2D). This meta-analysis evaluated salivary glucose, immunoglobulin A (IgA), total protein, and amylase levels in adult T2D compared with the controls as well as the correlation of salivary glucose levels with serum glucose and hemoglobin A1C (HbA1c) levels in both groups. MATERIALS AND
methodsWeb of Science, Scopus, PubMed, and Cochrane Library databases were searched up to July 2017. A random-effects analysis was performed using the mean difference (MD) and 95% confidence intervals. The search terms were "T2D, IgA, amylase, total protein, or glucose" combination with "saliva." The studied variables were the sample size, the percentage of male, the mean age, the condition of saliva sampling, and the salivary levels of mentioned factors.
resultsA total of 25 studies were included in this meta-analysis with 1432 and 900 diabetic patients and healthy controls, respectively. MD of salivary glucose level in patients with T2D, compared with the healthy controls, in fasting and nonfasting conditions were 6.23 mg/dL (
conclusionMeasurement of these salivary factors can be helpful for diagnostic and monitoring purposes of T2D. In addition, salivary glucose as a diagnostic tool can evaluate serum glucose and HbA1c levels in the diabetic patients.
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Registered trials
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