Evidence map›Paper›PMID 30505291›Full record

ReviewFrontiers in endocrinology2018

Particulate Matter Air Pollution: Effects on the Cardiovascular System.

Robert B Hamanaka, Gökhan M Mutlu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 206 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
206citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

206 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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  10. Particulate Matter and Premature Mortality: A Bayesian Meta-Analysis.International journal of environmental research and public health · 2021
    Pooled it
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  12. Trial
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  19. PMArchives of toxicology · 2026
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146 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Robert B HamanakaSection of Pulmonary and Critical Care Medicine, Department of Medicine, The University of Chicago, Chicago, IL, United States.
Gökhan M MutluSection of Pulmonary and Critical Care Medicine, Department of Medicine, The University of Chicago, Chicago, IL, United States.

Funding

Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
Role of alveolar macrophages in particulate matter-induced cardiopulmonary diseaseR01ES015024 · NIEHS · UNIVERSITY OF CHICAGO · PI MUTLU, GOKHAN M. · 2006 to 2022
$6.1M
Particulate matter-induced changes in DNA methylome and transcriptomeU01ES026718 · NIEHS · UNIVERSITY OF CHICAGO · PI MUTLU, GOKHAN M. · 2016 to 2019
$2.5M
Metabolic Regulation of Epidermal HomeostasisK01AR066579 · NIAMS · UNIVERSITY OF CHICAGO · PI HAMANAKA, ROBERT BRIAN · 2014 to 2018
$424k
NIAMS NIH HHS K01 AR066579NIEHS NIH HHS P30 ES027792NIEHS NIH HHS R01 ES015024NIEHS NIH HHS U01 ES026718
6 · The paper itself

Abstract

Air pollution is a complex mixture of gaseous and particulate components, each of which has detrimental effects on human health. While the composition of air pollution varies greatly depending on the source, studies from across the world have consistently shown that air pollution is an important modifiable risk factor for significantly increased morbidity and mortality. Moreover, clinical studies have generally shown a greater impact of particulate matter (PM) air pollution on health than the gaseous components. PM has wide-ranging deleterious effects on human health, particularly on the cardiovascular system. Both acute and chronic exposure to PM air pollution is associated with increased risk of death from cardiovascular diseases including ischemic heart disease, heart failure, and ischemic/thrombotic stroke. Particulate matter has also been shown to be an important endocrine disrupter, contributing to the development of metabolic diseases such as obesity and diabetes mellitus, which themselves are risk factors for cardiovascular disease. While the epidemiological evidence for the deleterious effects of PM air pollution on health is increasingly accepted, newer studies are shedding light on the mechanisms by which PM exerts its toxic effects. A greater understanding of how PM exerts toxic effects on human health is required in order to prevent and minimize the deleterious health effects of this ubiquitous environmental hazard. Air pollution is a growing public health problem and mortality due to air pollution is expected to double by 2050. Here, we review the epidemiological evidence for the cardiovascular effects of PM exposure and discuss current understanding about the biological mechanisms, by which PM exerts toxic effects on cardiovascular system to induce cardiovascular disease.

Indexed as

cardiovascularcoagulationinflammationinterleukin-6lungmacrophageparticulate matterthrombosis

Identifiers

PMID30505291
PMCPMC6250783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.