ArticleCrystal growth & design2018
Cocrystals Mitigate Negative Effects of High pH on Solubility and Dissolution of a Basic Drug.
Article in Crystal growth & design, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Dissolving microneedles incorporating kopexil multicomponent crystals for improved transdermal delivery.Drug delivery and translational research · 2026Article
- Formulation Strategies to Enhance the Solubility of Poorly Water-Soluble Drugs and Phytochemicals: Current Advances and Challenges.Pharmaceutics · 2026Review
- Drug Dissolution in Oral Drug Absorption: Workshop Report.The AAPS journal · 2023Article
- In Silico Screening as a Tool to Prepare Drug-Drug Cocrystals of Ibrutinib-Ketoconazole: a Strategy to Enhance Their Solubility Profiles and Oral Bioavailability.AAPS PharmSciTech · 2023Article
- Obtaining Cocrystals by Reaction Crystallization Method: Pharmaceutical Applications.Pharmaceutics · 2021Review
- Influence of the pACS omega · 2021Article
- Dissolution Advantage of Nitazoxanide Cocrystals in the Presence of Cellulosic Polymers.Pharmaceutics · 2019Article
- Article
- Engineering Cocrystals of PoorlyWater-Soluble Drugs to Enhance Dissolution in Aqueous Medium.Pharmaceutics · 2018Review
- Understanding the Differences Between Cocrystal and Salt Aqueous Solubilities.Journal of pharmaceutical sciences · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Weakly basic drugs are predisposed to order of magnitude decreases in solubility and dissolution as pH increases from 1 to 7 along the gastrointestinal tract. Such behavior is known to be detrimental to drug absorption. The work presented here shows how cocrystals of basic drugs with acidic coformers can mitigate these negative effects. Cocrystals of ketoconazole (KTZ) with adipic, fumaric, and succinic acids exhibit a parabolic solubility dependence on pH such that with increasing pH, solubility decreases, reaches a minimum, and increases. Cocrystals exhibit pH
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.