ArticleSaudi journal of biological sciences2018
Serum organochlorine pesticides residues and risk of cancer: A case-control study.
Article in Saudi journal of biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 82 citations in OpenAlex.
- Tissue levels of persistent organic pollutants and biotransformation enzyme polymorphisms in human stomach cancer.Cancer causes & control : CCC · 2026Article
- ZIF-8 modified Citrus reticulata peel carbon aerogel as solid-phase microextraction coating for the determination of organochlorine pesticides.Mikrochimica acta · 2025Article
- Review
- Exposure to pesticides in Chile and its relationship with carcinogenic potential: a review.Frontiers in public health · 2025Review
- Occurrence and seasonal variation of organochlorine pesticides in selected vegetable farmlands in Lagos State, Nigeria.Environmental analysis, health and toxicology · 2024Article
- Article
- Consumer Awareness and Health Risk Perceptions of Pesticide Residues in Fruits and Vegetables in Kampala Metropolitan Area in Uganda.Environmental health insights · 2023Article
- Correlation between Lindane Use and the Incidence of Thyroid Cancer in the United States: An Ecological Study.International journal of environmental research and public health · 2022Article
- Risk of exposure to Hg and pesticides residues in a traditional fishing community in the Amazon: a probabilistic approach based on dietary pattern.Environmental science and pollution research international · 2022Article
- Insights on the bioremediation technologies for pesticide-contaminated soils.Environmental geochemistry and health · 2022Article
- Effects of Endocrine DisruptorsToxics · 2022Article
- The effect of the pesticide delivery method on the microbial community of field soil.Environmental science and pollution research international · 2021Article
- Exposure to organochlorine pesticides as a predictor to breast cancer: A case-control study among Ethiopian women.PloS one · 2021Article
- Glutathione S-transferase activity and genetic polymorphisms associated with exposure to organochloride pesticides in Todos Santos, BCS, Mexico: a preliminary study.Environmental science and pollution research international · 2020Article
- Determination of Selected Priority Pesticides in High Water Fruits and Vegetables by Modified QuEChERS and GC-ECD with GC-MS/MS Confirmation.Molecules (Basel, Switzerland) · 2019Article
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Authors and funding
10 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Organochlorine pesticides (OCPs) are frequently used worldwide as insecticides, fungicides, herbicides and termiticides and have been associated with a variety of cancers in animal and human studies. In the present study, we examined residues of fourteen OCPs in the serum samples of diagnosed cancer patients and healthy residents of Karachi, Pakistan. A random collection of fasting blood samples was carried out from the donors with informed consent. Serum was separated within 2 h of blood collection and was then subjected to extraction with organic solvents followed by purification with florisil column. The final organic extract of each serum sample was processed with Gas Chromatograph coupled with Electron Capture Detector (GC-ECD). OCPs were detected in 97.59% of the cancer cases and 93.75% of the healthy subjects. Mean concentrations of total OCPs (ΣOCPs) was found elevated in the cancer group (0.606 mg/kg) compared with the control group (0.322 mg/kg). Endosulfan was the highest prevalent OCP with a mean concentration of 0.214 mg/kg in the cancer group and 0.166 mg/kg in the control group. The second most prevalent OCP was 4,4-DDE with a mean concentration of 0.131 mg/kg in the cancer group and 0.019 mg/kg in the control group. Highest level of ΣOCPs was detected in the breast cancer cases (20.411 mg/kg) with a mean level of (2.041 mg/kg). In light of the obtained results and available literature on the subject, it has been concluded that OCPs are positively associated with the risk of various cancers in humans.
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