Evidence map›Paper›PMID 30504921›Full record

ReviewNature communications2018

Immediate neurophysiological effects of transcranial electrical stimulation.

Anli Liu, Mihály Vöröslakos, Greg Kronberg, Simon Henin, Matthew R Krause, Yu Huang, Alexander Opitz, Ashesh Mehta, Christopher C Pack, Bart Krekelberg and 5 more

2 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 275 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
275citing papers in PubMed, 5 pooled it
21.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05788042 narecruitingnot on this mapstarted 2023, after this paper: background citation

Randomised Controlled Trial of Neurostimulation for Symptoms of Anorexia Nervosa

TypeinterventionalSponsorThe George InstituteRan2023 to 2026Enrolled70ConditionsAnorexia NervosaArmsMagPro TMS device (ARTG: 204659), tDCS mini-CT Stimulator (Soterix, USA: ARTG: 284637)
NCT06558890 naunknown statusnot on this mapstarted 2024, after this paper: background citation

A Study on the Efficacy and Mechanism of Targeted Cerebellar Transcranial Electrical Stimulation for the Treatment of Refractory Temporal Lobe Epilepsy: A Single-center, Observational Study.

TypeinterventionalSponsorXijing HospitalRan2024 to 2024Enrolled60ConditionsTranscranial Electrical Stimulation, Temporal Lobe Epilepsy, Magnetic Resonance Imaging, ElectroencephalogramArmsTranscranial Alternating Current Stimulation
3 · Its place in the literature

Who cites it

275 citing papers in PubMed, 5 syntheses or guidelines pooled it, 603 citations in OpenAlex.

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215 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 4 countries.

Anli LiuNew York University Comprehensive Epilepsy Center, 223 34th Street, New York, NY, 10016, USA. anli.liu@nyumc.org.ORCID http://orcid.org/0000-0002-1118-981X
Mihály VöröslakosMTA-SZTE 'Momentum' Oscillatory Neuronal Networks Research Group, Department of Physiology, Faculty of Medicine, University of Szeged, 10 Dom sq., Szeged, H-6720, Hungary.
Greg KronbergDepartment of Biomedical Engineering, City College of New York, 160 Convent Ave, New York, NY, 10031, USA.
Simon HeninNew York University Comprehensive Epilepsy Center, 223 34th Street, New York, NY, 10016, USA.ORCID http://orcid.org/0000-0003-0997-3266
Matthew R KrauseMontreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada.ORCID http://orcid.org/0000-0002-1837-687X
Yu HuangDepartment of Biomedical Engineering, City College of New York, 160 Convent Ave, New York, NY, 10031, USA.
Alexander OpitzDepartment of Biomedical Engineering of Minnesota, 312 Church St. SE, Minneapolis, MN, 55455, USA.
Ashesh MehtaDepartment of Neurosurgery, Hofstra Northwell School of Medicine, 611 Northern Blvd, Great Neck, NY, 11021, USA.
Christopher C PackMontreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada.
Bart KrekelbergCenter for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue, Newark, NJ, 07102, USA.
Antal BerényiMTA-SZTE 'Momentum' Oscillatory Neuronal Networks Research Group, Department of Physiology, Faculty of Medicine, University of Szeged, 10 Dom sq., Szeged, H-6720, Hungary.ORCID http://orcid.org/0000-0003-0084-8530
Lucas C ParraDepartment of Biomedical Engineering, City College of New York, 160 Convent Ave, New York, NY, 10031, USA.ORCID http://orcid.org/0000-0003-4667-816X
Lucia MelloniNew York University Comprehensive Epilepsy Center, 223 34th Street, New York, NY, 10016, USA.
Orrin DevinskyNew York University Comprehensive Epilepsy Center, 223 34th Street, New York, NY, 10016, USA.
György BuzsákiNew York University Neuroscience Institute, 435 East 30th Street, New York, NY, 10016, USA. gyorgy.buzsaki@nyumc.org.ORCID http://orcid.org/0000-0002-3100-4800
City College of New York · USNYU Langone Health · USMontreal Neurological Institute and Hospital · CAUniversity of Szeged · HUFeinstein Institute for Medical Research · USMax Planck Institute for Empirical Aesthetics · DENew York University · USRutgers, The State University of New Jersey · USUniversity of Minnesota · US

Funding

Training and Career Development CoreU54CA132378 · NCI · CITY COLLEGE OF NEW YORK · PI Bao Q Vuong · 2008 to 2026
$28.9M
Training and Career Development and Education CoreU54CA137788 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ADRIANA ESPINOSA, FRANCESCA M GANY · 2008 to 2026
$28.1M
Brain rhythms-assisted memory enhancementR01MH107396 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BUZSAKI, GYORGY, DEVINSKY, ORRIN · 2015 to 2019
$3.3M
Mechanisms of disrupted memory encoding in epilepsy patients - Resubmission - 1K23NS104252 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LIU, ANLI A · 2018 to 2022
$1.0M
NCI NIH HHS U54 CA132378NCI NIH HHS U54 CA137788NIMH NIH HHS R01 MH107396NINDS NIH HHS K23 NS104252
6 · The paper itself

Abstract

Noninvasive brain stimulation techniques are used in experimental and clinical fields for their potential effects on brain network dynamics and behavior. Transcranial electrical stimulation (TES), including transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS), has gained popularity because of its convenience and potential as a chronic therapy. However, a mechanistic understanding of TES has lagged behind its widespread adoption. Here, we review data and modelling on the immediate neurophysiological effects of TES in vitro as well as in vivo in both humans and other animals. While it remains unclear how typical TES protocols affect neural activity, we propose that validated models of current flow should inform study design and artifacts should be carefully excluded during signal recording and analysis. Potential indirect effects of TES (e.g., peripheral stimulation) should be investigated in more detail and further explored in experimental designs. We also consider how novel technologies may stimulate the next generation of TES experiments and devices, thus enhancing validity, specificity, and reproducibility.

Indexed as

AnimalsBrainElectroencephalographyHumansNeurophysiologyTranscranial Direct Current Stimulation

Identifiers

PMID30504921
PMCPMC6269428
OpenAlexW2903380895

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.