Evidence map›Paper›PMID 30504918›Full record

ArticleThe Journal of antibiotics2019

Fluorescence assay to predict activity of the glycopeptide antibiotics.

Vladimir Vimberg, Radek Gazak, Zsolt Szűcs, Aniko Borbás, Pal Herczegh, Jorunn Pauline Cavanagh, Leona Zieglerova, Jan Závora, Václava Adámková, Gabriela Balikova Novotna

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in The Journal of antibiotics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Teicoplanin-A New Use for an Old Drug in the COVID-19 Era?Pharmaceuticals (Basel, Switzerland) · 2021
    Review
  6. Two Novel Semisynthetic Lipoglycopeptides Active againstPharmaceuticals (Basel, Switzerland) · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Vladimir VimbergInstitute of Microbiology v. v. i., Czech Academy of Sciences, Vestec, Czech Republic. vladimir.vimberg@biomed.cas.cz.
Radek GazakInstitute of Microbiology v. v. i., Czech Academy of Sciences, Vestec, Czech Republic.
Zsolt SzűcsDepartment of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Hungary.
Aniko BorbásDepartment of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Hungary.
Pal HerczeghDepartment of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Hungary.
Jorunn Pauline CavanaghDepartment of Pediatrics, University Hospital of North Norway, Tromsø, Norway.
Leona ZieglerovaInstitute of Microbiology v. v. i., Czech Academy of Sciences, Vestec, Czech Republic.
Jan ZávoraClinical Microbiology and ATB Centre, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital, Prague, Czech Republic.
Václava AdámkováClinical Microbiology and ATB Centre, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital, Prague, Czech Republic.
Gabriela Balikova NovotnaInstitute of Microbiology v. v. i., Czech Academy of Sciences, Vestec, Czech Republic.
University of Debrecen · HUCzech Academy of Sciences · CZCzech Academy of Sciences, Institute of Microbiology · CZGeneral University Hospital in Prague · CZUiT The Arctic University of Norway · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here, we describe a fluorescent assay developed to study competitive binding of the glycopeptide antibiotics to live bacteria cells. This assay demonstrated that the mechanism of action of the lipoglycopeptide antibiotics strongly depends on the hydrophobicity of the substitutes, with the best antibacterial activity of the glycopeptide antibiotics equally sharing properties of binding to D-Ala-D-Ala residues of the nascent peptidoglycan and to the membrane.

Indexed as

Anti-Bacterial AgentsCell WallEnterococcus faeciumFluorescenceGlycopeptidesLipoglycopeptidesMicrobial Sensitivity TestsPeptidoglycanProtein BindingRhodaminesStaining and LabelingStaphylococcus aureusTeicoplaninVancomycinVancomycin-Resistant EnterococciAnti-Bacterial AgentsdalbavancinGlycopeptidesLipoglycopeptidesoritavancinPeptidoglycanrhodamine isothiocyanateRhodaminesTeicoplaninVancomycin

Identifiers

PMID30504918
OpenAlexW2903497646

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.