ArticleNature methods2018
Brain-wide circuit interrogation at the cellular level guided by online analysis of neuronal function.
Article in Nature methods, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 74 citations in OpenAlex.
- Developmental and genetic modulation of evidence integration dynamics in zebrafish sensorimotor decision-making.bioRxiv : the preprint server for biology · 2026Article
- Negative-Valence Neurons in the Larval Zebrafish Pallium.bioRxiv : the preprint server for biology · 2026Article
- A software platform for real-time and adaptive neuroscience experiments.Nature communications · 2025Article
- Deep learning enhanced deciphering of brain activity maps for discovery of therapeutics for brain disorders.iScience · 2025Article
- Homeostasis of a representational map in the neocortex.Nature neuroscience · 2025Article
- A sensitive soma-localized red fluorescent calcium indicator for in vivo imaging of neuronal populations at single-cell resolution.PLoS biology · 2025Article
- Unifying community whole-brain imaging datasets enables robust neuron identification and reveals determinants of neuron position in C. elegans.Cell reports methods · 2025Article
- Closing the Experiment-Modeling-Perturbation Loop in Whole-Brain Neuroscience.Neuroscience bulletin · 2024Article
- Unifying community-wide whole-brain imaging datasets enables robust automated neuron identification and reveals determinants of neuron positioning inbioRxiv : the preprint server for biology · 2024Article
- Real-time analysis of large-scale neuronal imaging enables closed-loop investigation of neural dynamics.Nature neuroscience · 2024Article
- The influence of cortical activity on perception depends on behavioral state and sensory context.Nature communications · 2024Article
- Automatic monitoring of neural activity with single-cell resolution in behaving Hydra.Scientific reports · 2024Article
- All-optical interrogation of brain-wide activity in freely swimming larval zebrafish.iScience · 2024Article
- Holographic Optogenetic Activation of Neurons Eliciting Locomotion in Head-Embedded Larval Zebrafish.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Automatic monitoring of whole-body neural activity in behavingbioRxiv : the preprint server for biology · 2023Article
- FIOLA: an accelerated pipeline for fluorescence imaging online analysis.Nature methods · 2023Article
- Advances in Zebrafish as a Comprehensive Model of Mental Disorders.Depression and anxiety · 2023Review
- Article
- Optic flow in the natural habitats of zebrafish supports spatial biases in visual self-motion estimation.Current biology : CB · 2022Article
- A single-cell transcriptomic atlas of complete insect nervous systems across multiple life stages.Neural development · 2022Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whole-brain imaging allows for comprehensive functional mapping of distributed neural pathways, but neuronal perturbation experiments are usually limited to targeting predefined regions or genetically identifiable cell types. To complement whole-brain measures of activity with brain-wide manipulations for testing causal interactions, we introduce a system that uses measured activity patterns to guide optical perturbations of any subset of neurons in the same fictively behaving larval zebrafish. First, a light-sheet microscope collects whole-brain data that are rapidly analyzed by a distributed computing system to generate functional brain maps. On the basis of these maps, the experimenter can then optically ablate neurons and image activity changes across the brain. We applied this method to characterize contributions of behaviorally tuned populations to the optomotor response. We extended the system to optogenetically stimulate arbitrary subsets of neurons during whole-brain imaging. These open-source methods enable delineating the contributions of neurons to brain-wide circuit dynamics and behavior in individual animals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.