ArticleScientific reports2018
Pretreatment with Total Flavonoid Extract from Dracocephalum Moldavica L. Attenuates Ischemia Reperfusion-induced Apoptosis.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Phytochemical Composition and Biological Activities ofPlants (Basel, Switzerland) · 2026Review
- Precision Intervention of Isorhamnetin Total Flavonoids in Ischemic Heart Failure: Mechanistic Exploration Based on Signature Gene Targets.Current issues in molecular biology · 2026Article
- A Comprehensive Review of the Phenolic Compounds inMolecules (Basel, Switzerland) · 2025Review
- Investigating the neuroprotective effects ofHeliyon · 2025Article
- Optimization of Liquid Fermentation ofMolecules (Basel, Switzerland) · 2024Article
- MicroRNA-specific therapeutic targets and biomarkers of apoptosis following myocardial ischemia-reperfusion injury.Molecular and cellular biochemistry · 2024Review
- Natural Products Targeting PI3K/AKT in Myocardial Ischemic Reperfusion Injury: A Scoping Review.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Evaluation of the Cytotoxic, Antioxidative and Antimicrobial Effects ofMolecules (Basel, Switzerland) · 2023Article
- Short-term pretreatment of naringin isolated from Citrus wilsonii Tanaka attenuates rat myocardial ischemia/reperfusion injury.Naunyn-Schmiedeberg's archives of pharmacology · 2022Article
- Systems Pharmacology-Based Strategy to Investigate Pharmacological Mechanisms of Total Flavonoids inInternational journal of molecular sciences · 2022Article
- Chemical Composition, Antioxidant, and Antimicrobial Activity ofPlants (Basel, Switzerland) · 2022Article
- Mitochondrial Damage in Myocardial Ischemia/Reperfusion Injury and Application of Natural Plant Products.Oxidative medicine and cellular longevity · 2022Review
- Flavonoids in myocardial ischemia-reperfusion injury: Therapeutic effects and mechanisms.Chinese herbal medicines · 2021Review
- Identification of miRNA and Their Regulatory Effects Induced by Total Flavonoids FromFrontiers in pharmacology · 2021Article
- Important Flavonoids and Their Role as a Therapeutic Agent.Molecules (Basel, Switzerland) · 2020Review
- Transformed Shoots ofMolecules (Basel, Switzerland) · 2020Article
- Total flavones of Dracocephalum moldavica L. protect astrocytes against HBMC complementary medicine and therapies · 2020Article
- Article
- Role of Programmed Cell Death 4 (PDCD4)-Mediated Akt Signaling Pathway in Vascular Endothelial Cell Injury Caused by Lower-Extremity Ischemia-Reperfusion in Rats.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Dose-Dependent Cardioprotection of Pterocarpus indicus Extract in Rats With Myocardial Ischemia: Targeting Oxidative Stress, Inflammation, and Apoptosis.Dose-response : a publication of International Hormesis SocietyArticle
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously demonstrated the cardio-protection mediated by the total flavonoid extracted from Dracocephalum moldavica L. (TFDM) following myocardial ischemia reperfusion injury (MIRI). The present study assessed the presence and mechanism of TFDM-related cardio-protection on MIRI-induced apoptosis in vivo. Male Sprague-Dawley rats experienced 45-min ischemia with 12 h of reperfusion. Rats pretreated with TFDM (3, 10 or 30 mg/kg/day) were compared with Sham (no MIRI and no TFDM), MIRI (no TFDM), and Positive (trapidil tablets, 13.5 mg/kg/day) groups. In MIRI-treated rats, high dose-TFDM (H-TFDM) pre-treatment with apparently reduced release of LDH, CK-MB and MDA, enhanced the concentration of SOD in plasma, and greatly reduced the infarct size, apoptotic index and mitochondrial injury. H-TFDM pretreatment markedly promoted the phosphorylation of PI3K, Akt, GSK-3β and ERK1/2 in comparison with the MIRI model group. Western blot analysis after reperfusion also showed that H-TFDM decreased release of Bax, cleaved caspase-3, caspase-7 and caspase-9, and increased expression of Bcl-2 as evident by the higher Bcl-2/Bax ratio. TFDM cardio-protection was influenced by LY294002 (PI3K inhibitor) and PD98059 (ERK1/2 inhibitor). Taken together, these results provide convincing evidence of the benefit of TFDM pretreatment due to inhibited myocardial apoptosis as mediated by the PI3K/Akt/GSK-3β and ERK1/2 signaling pathways.
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