Evidence map›Paper›PMID 30504823›Full record

ArticleMolecular psychiatry2020

Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP.

A D Nelson, R N Caballero-Florán, J C Rodríguez Díaz, J M Hull, Y Yuan, J Li, K Chen, K K Walder, L F Lopez-Santiago, V Bennett and 6 more

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Molecular psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 59 citations in OpenAlex.

  1. Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Reframing the axon initial segment: Giant ankyrin-G as a modulator of excitability and plasticity in neurodevelopment.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
  8. Review
  9. A neuron type-specific microexon inbioRxiv : the preprint server for biology · 2025
    Article
  10. Impaired AIS plasticity in ankyrin-G mutant mice alters cortical excitability and behavior.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Review
  13. Proteostasis regulation of GABABiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
    Review
  14. Article
  15. Article
  16. Live imaging of excitable axonal microdomains in ankyrin-G-GFP mice.bioRxiv : the preprint server for biology · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Lithium rescues dendritic abnormalities in Ank3 deficiency models through the synergic effects of GSK3β and cyclic AMP signaling pathways.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

A D NelsonDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
R N Caballero-FloránDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
J C Rodríguez DíazNeuroscience Graduate Program, University of Michigan, Ann Arbor, MI, 48109, USA.
J M HullDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Y YuanDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
J LiDivision of Life Sciences, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.ORCID http://orcid.org/0000-0002-8921-1626
K ChenDivision of Life Sciences, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
K K WalderDepartment of Cell Biology, Duke University Medical Center, Durham, NC, 27710, USA.
L F Lopez-SantiagoDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
V BennettDepartment of Cell Biology, Duke University Medical Center, Durham, NC, 27710, USA.
M G McInnisDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0002-0375-6247
L L IsomDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
C WangDivision of Life Sciences, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.ORCID http://orcid.org/0000-0003-3192-2780
M ZhangDivision of Life Sciences, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.ORCID http://orcid.org/0000-0001-9404-0190
K S JonesDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
P M JenkinsDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA. pjenkins@umich.edu.ORCID http://orcid.org/0000-0002-4207-5823
University of Michigan · USHong Kong University of Science and Technology · HKDuke University · USHoward Hughes Medical Institute · USUniversity of Science and Technology of China · CN

Funding

PREDOCTORAL TRAINING IN GENETICST32GM007544 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORAN, JOHN V. · 1985 to 2022
$11.3M
Development of the Basal Telencephalic Limbic SystemR01DA020140 · NIDA · GEORGETOWN UNIVERSITY · PI CORBIN, JOSHUA G · 2006 to 2020
$7.3M
Role of SCN1B in Inherited EpilepsyR37NS076752 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ISOM, LORI L. · 2017 to 2023
$4.8M
Early Stage Training in the NeurosciencesT32NS076401 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Carol Fuzeti Elias, LESLIE S. SATIN · 2011 to 2026
$3.1M
Role of Sodium Channel SCN1B in Inherited EpilepsyR01NS076752 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ISOM, LORI L. · 2011 to 2014
$1.6M
Howard Hughes Medical InstituteNIDA NIH HHS R01 DA020140NIGMS NIH HHS T32 GM007544NINDS NIH HHS R01 NS076752NINDS NIH HHS R37 NS076752NINDS NIH HHS T32 NS076401
6 · The paper itself

Abstract

GABAergic circuits are critical for the synchronization and higher order function of brain networks. Defects in this circuitry are linked to neuropsychiatric diseases, including bipolar disorder, schizophrenia, and autism. Work in cultured neurons has shown that ankyrin-G plays a key role in the regulation of GABAergic synapses on the axon initial segment and somatodendritic domain of pyramidal neurons, where it interacts directly with the GABA

Indexed as

Neural PathwaysAdultAgedAnimalsAnkyrinsApoptosis Regulatory ProteinsBipolar DisorderCells, CulturedFemaleGABAergic NeuronsHumansMaleMiceMicrotubule-Associated ProteinsMiddle AgedProsencephalonANK3 protein, humanAnk3 protein, mouseAnkyrinsApoptosis Regulatory ProteinsGABARAP protein, humanGABARAP protein, mouseMicrotubule-Associated Proteins

Identifiers

PMID30504823
PMCPMC6542726
OpenAlexW2798508824

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.