Evidence map›Paper›PMID 30504791›Full record

ArticleScientific reports2018

New Spirometry Indices for Detecting Mild Airflow Obstruction.

Surya P Bhatt, Nirav R Bhakta, Carla G Wilson, Christopher B Cooper, Igor Barjaktarevic, Sandeep Bodduluri, Young-Il Kim, Michael Eberlein, Prescott G Woodruff, Frank C Sciurba and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Pre-COPD: Impact on prevention, detection, and treatment.Presse medicale (Paris, France : 1983) · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Curve-Modelling and Machine Learning for a Better COPD Diagnosis.International journal of chronic obstructive pulmonary disease · 2024
    Observational
  11. Optimal Threshold of FEVAmerican journal of respiratory and critical care medicine · 2023
    Article
  12. Parameter D: New Measure of Airflow Obstruction.Annals of the American Thoracic Society · 2023
    Article
  13. La Tunisie medicale · 2023
    Article
  14. Article
  15. Article
  16. The Challenges of Spirometric Diagnosis of COPD.Canadian respiratory journal · 2023
    Review
  17. Article
  18. Significance of FEVChest · 2022
    Observational
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Surya P BhattDivision of Pulmonary, Allergy and Critical Care Medicine and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL, 35294, USA. sbhatt@uabmc.edu.
Nirav R BhaktaDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, University California San Francisco, San Francisco, CA, 94143, USA.
Carla G WilsonDepartment of Biostatistics and Bioinformatics, National Jewish Health, Denver, CO, 80206, USA.
Christopher B CooperDivision of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at the University California Los Angeles, Los Angeles, CA, 90095, USA.
Igor BarjaktarevicDivision of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at the University California Los Angeles, Los Angeles, CA, 90095, USA.
Sandeep BodduluriDivision of Pulmonary, Allergy and Critical Care Medicine and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Young-Il KimDivision of Pulmonary, Allergy and Critical Care Medicine and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Michael EberleinDivision of Pulmonary, Critical Care and Occupational Medicine, University of Iowa Hospital, Iowa City, IA, 52242, USA.
Prescott G WoodruffDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, University California San Francisco, San Francisco, CA, 94143, USA.
Frank C SciurbaDivision of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Peter J CastaldiChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
MeiLan K HanDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
Mark T DransfieldDivision of Pulmonary, Allergy and Critical Care Medicine and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Arie NakhmaniDepartment of Electrical and Computer Engineering, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.ORCID http://orcid.org/0000-0002-0987-4834

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Metabolomic signatures of empysema and COPD progression in the COPDGene cohortR01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2012 to 2016
$31.1M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
Redefining Therapy In Early COPD: RETHINCU01HL128952 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAN, MEILAN K, WOODRUFF, PRESCOTT G · 2015 to 2020
$1.6M
Mentoring Research in Precision Medicine for Lung DiseaseK24HL137013 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2017 to 2026
$1.2M
Diastolic Dysfunction and Pauci-inflammatory Acute Exacerbations of Chronic Obstructive Pulmonary DiseaseK23HL133438 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BHATT, SURYA P. · 2016 to 2020
$921k
UAB Mentoring Program in COPD Patient Oriented ResearchK24HL140108 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DRANSFIELD, MARK T · 2018 to 2022
$439k
NHLBI NIH HHS K23 HL133438NHLBI NIH HHS K24 HL137013NHLBI NIH HHS K24 HL140108NHLBI NIH HHS R01 HL089897NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NHLBI NIH HHS U01 HL128952NIDDK NIH HHS P30 DK054759
6 · The paper itself

Abstract

The diagnosis of chronic obstructive pulmonary disease (COPD) relies on demonstration of airflow obstruction. Traditional spirometric indices miss a number of subjects with respiratory symptoms or structural lung disease on imaging. We hypothesized that utilizing all data points on the expiratory spirometry curves to assess their shape will improve detection of mild airflow obstruction and structural lung disease. We analyzed spirometry data of 8307 participants enrolled in the COPDGene study, and derived metrics of airflow obstruction based on the shape on the volume-time (Parameter D), and flow-volume curves (Transition Point and Transition Distance). We tested associations of these parameters with CT measures of lung disease, respiratory morbidity, and mortality using regression analyses. There were significant correlations between FEV

Indexed as

SpirometryAgedAirway ObstructionComorbidityFemaleForced Expiratory VolumeHumansImage Processing, Computer-AssistedMaleMiddle AgedOdds RatioPrognosisPulmonary Disease, Chronic ObstructiveRespiratory Function TestsSeverity of Illness IndexTomography, X-Ray Computed

Identifiers

PMID30504791
PMCPMC6269456

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.