ArticleNature communications2018
Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Yorkie/YAP Interactors: Fine-Tuning the Hippo Pathway Output.Cold Spring Harbor perspectives in biology · 2026Article
- A large-scale sORF screen identifies putative microproteins involved in cancer cell fitness.iScience · 2025Article
- Role of YAP/TAZ in bone diseases: A transductor from mechanics to biology.Journal of orthopaedic translation · 2025Review
- Small ORFs, Big Insights:Cells · 2024Review
- Pri peptides temporally coordinate transcriptional programs during epidermal differentiation.Science advances · 2024Article
- Crosstalk between chromatin and Shavenbaby defines transcriptional output along the Drosophila intestinal stem cell lineage.iScience · 2024Article
- Compromised junctional integrity phenocopies age-dependent renal dysfunction in Drosophila Snakeskin mutants.Journal of cell science · 2023Article
- The pleiotropic functions of Pri smORF peptides synchronize leg development regulators.PLoS genetics · 2023Article
- Hippo pathway and Bonus control developmental cell fate decisions in the Drosophila eye.Developmental cell · 2023Article
- Metabolic control of progenitor cell propagation during Drosophila tracheal remodeling.Nature communications · 2022Article
- Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance.Nature communications · 2021Article
- Steroid-dependent switch of OvoL/Shavenbaby controls self-renewal versus differentiation of intestinal stem cells.The EMBO journal · 2021Article
- Pri smORF Peptides Are Wide Mediators of Ecdysone Signaling, Contributing to Shape Spatiotemporal Responses.Frontiers in genetics · 2021Article
- Hippo-Independent Regulation of Yki/Yap/Taz: A Non-canonical View.Frontiers in cell and developmental biology · 2021Review
- Yes‑associated protein protects and rescues SH‑SY5Y cells from ketamine‑induced apoptosis.Molecular medicine reports · 2020Article
- Physiology, Development, and Disease Modeling in theGenetics · 2020Review
- Influence of hyperproteinemia on reproductive development in an invertebrate model.International journal of biological sciences · 2019Article
- The mammalian cholesterol synthesis enzyme squalene monooxygenase is proteasomally truncated to a constitutively active form.The Journal of biological chemistryArticle
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 3 countries.
Funding
Abstract
To compensate for accumulating damages and cell death, adult homeostasis (e.g., body fluids and secretion) requires organ regeneration, operated by long-lived stem cells. How stem cells can survive throughout the animal life remains poorly understood. Here we show that the transcription factor Shavenbaby (Svb, OvoL in vertebrates) is expressed in renal/nephric stem cells (RNSCs) of Drosophila and required for their maintenance during adulthood. As recently shown in embryos, Svb function in adult RNSCs further needs a post-translational processing mediated by the Polished rice (Pri) smORF peptides and impairing Svb function leads to RNSC apoptosis. We show that Svb interacts both genetically and physically with Yorkie (YAP/TAZ in vertebrates), a nuclear effector of the Hippo pathway, to activate the expression of the inhibitor of apoptosis DIAP1. These data therefore identify Svb as a nuclear effector in the Hippo pathway, critical for the survival of adult somatic stem cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.